Elevated osteoprotegerin is associated with abnormal ankle brachial indices in patients infected with HIV: a cross-sectional study
Elevated osteoprotegerin is associated with abnormal ankle brachial indices in patients infected with HIV: a cross-sectional study
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DOI：
10.1186/1758-2652-13-12
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发表时间：
2010-03-22
影响因子：
6
通讯作者：
Schecter, Alison D.
中科院分区：
文献类型：
--
作者：
Jang, James J.;Schwarcz, Aron I.;Schecter, Alison D.
背景：HIV感染者加速动脉粥样硬化的风险增加。骨保护素（一种炎性细胞因子受体）水平升高与心血管疾病（包括外周动脉疾病或PAD）、急性冠状动脉综合征和心血管死亡率的高发病率相关。本研究的目的是确定PAD是否在HIV感染人群中普遍存在，并确定与HIV特异性和传统心血管危险因素以及骨保护素水平的相关性。方法：招募了102例HIV感染患者进行横断面研究。为了确定PAD的患病率，测量踝臂指数（ABI）。使用了四个标准ABI类别：1.30（高）。收集病史和实验室检查结果，以确定HIV感染者PAD的可能危险因素。
Background: Patients infected with HIV have an increased risk for accelerated atherosclerosis. Elevated levels of osteoprotegerin, an inflammatory cytokine receptor, have been associated with a high incidence of cardiovascular disease (including peripheral arterial disease, or PAD), acute coronary syndrome, and cardiovascular mortality. The objective of this study was to determine whether PAD is prevalent in an HIV-infected population, and to identify an association with HIV-specific and traditional cardiovascular risk factors, as well as levels of osteoprotegerin.Methods: One hundred and two patients infected with HIV were recruited in a cross-sectional study. To identify the prevalence of PAD, ankle-brachial indices (ABIs) were measured. Four standard ABI categories were utilized: 1.30 (high). Medical history and laboratory measurements were obtained to determine possible risk factors associated with PAD in HIV-infected patients.Results: The prevalence of PAD (ABI