EFFECT OF ANTIDEPRESSANT DRUGS ON DEPLETION OF INTRANEURONAL BRAIN 5-HYDROXYTRYPTAMINE STORES CAUSED BY 4-METHYL-ALPHA-ETHYL-META-TYRAMINE
EFFECT OF ANTIDEPRESSANT DRUGS ON DEPLETION OF INTRANEURONAL BRAIN 5-HYDROXYTRYPTAMINE STORES CAUSED BY 4-METHYL-ALPHA-ETHYL-META-TYRAMINE
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DOI：
10.1016/0014-2999(69)90113-7
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发表时间：
1969-01-01
影响因子：
5
通讯作者：
HOKFELT, T
中科院分区：
文献类型：
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作者：
CARLSSON, A;CORRODI, H;HOKFELT, T
给小鼠注射4-甲基-α-乙基-间-酪胺（100 mg/kg i. p.，两次给药）。4小时后，处死动物，并对脑进行5-羟色胺（5-HT）生化分析或在甲醛处理后在荧光显微镜下检查。胺引起50%以上的5-HT消耗，可能是通过置换。预先用丙咪嗪类抗抑郁药处理，很大程度上防止了5-HT耗竭，可能是通过阻断5-HT神经元细胞膜的胺摄取机制。叔胺，如氯丙咪嗪，丙咪嗪和阿米替林，在这方面比相应的仲胺更有效，在去甲肾上腺素神经元上的先前的观察相反。在大鼠中进行了类似的观察（仅组织化学观察）。有人建议，5-HT再摄取的封锁参与情绪提升作用的三环类抗抑郁药，而去甲肾上腺素再摄取的封锁，促进抑郁症患者的驱动器。
Mice were injected with 4-methyl-α-ethyl-meta-tyramine (two doses of 100 mg/kg i.p.). After 4 h the animals were killed and the brains analyzed for 5-hydroxytryptamine (5-HT) biochemically or examined under the fluorescence microscope after formaldehyde treatment. The amine caused more than 50 per cent depletion of 5-HT, probably by displacement. Pretreatment with antidepressant drugs of imipramine type largely prevented 5-HT depletion, probably by blocking the amine uptake mechanism of the cell membrane of 5-HT neurons. Tertiary amines, e.g. chlorimipramine, imipramine and amitriptyline, were more potent in this respect than the corresponding secondary amines, in contrast to previous observations on noradrenaline neurons. In rats similar observations were made (histochemical observations only). It is suggested that blockade of 5-HT re-uptake is involved in the mood-elevating action of tricyclic antidepressants, whereas blockade of noradrenaline re-uptake promotes drive in the depressed patient.