Rapid rewiring of arcuate nucleus feeding circuits by leptin
Rapid rewiring of arcuate nucleus feeding circuits by leptin
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DOI：
10.1126/science.1089459
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发表时间：
2004-04-02
期刊：
影响因子：
56.9
通讯作者：
Horvath, TL
中科院分区：
文献类型：
--
作者：
Pinto, S;Roseberry, AG;Horvath, TL
脂肪源性激素瘦素通过调节下丘脑弓状核中神经肽Y和阿黑皮素原神经元的活性来调节能量平衡。为了研究这些神经元的内在活性及其对瘦素的反应，我们产生了在这两种神经元类型中表达不同绿色荧光蛋白的小鼠。瘦素缺陷（ob/ob）小鼠与野生型小鼠在神经肽Y和阿黑皮素原神经元上的兴奋性和抑制性突触和突触后电流的数量上不同。当瘦素被全身性地传递到ob/ob小鼠时，突触密度迅速正常化，在瘦素对食物摄入的影响之前的几个小时，在6小时内可检测到这种影响。这些数据表明，瘦素介导的可塑性在ob/ob下丘脑可能是一些激素的行为效应的基础。
The fat-derived hormone leptin regulates energy balance in part by modulating the activity of neuropeptide Y and proopiomelanocortin neurons in the hypothalamic arcuate nucleus. To study the intrinsic activity of these neurons and their responses to leptin, we generated mice that express distinct green fluorescent proteins in these two neuronal types. Leptin-deficient (ob/ob) mice differed from wild-type mice in the numbers of excitatory and inhibitory synapses and postsynaptic currents onto neuropeptide Y and proopiomelanocortin neurons. When leptin was delivered systemically to ob/ob mice, the synaptic density rapidly normalized, an effect detectable within 6 hours, several hours before leptin's effect on food intake. These data suggest that leptin-mediated plasticity in the ob/ob hypothalamus may underlie some of the hormone's behavioral effects.