Breast Arterial Calcifications on Mammograms Do Not Predict Coronary Heart Disease at Coronary Angiography
Breast Arterial Calcifications on Mammograms Do Not Predict Coronary Heart Disease at Coronary Angiography
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DOI：
10.1148/radiol.09090102
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发表时间：
2010-02-01
期刊：
影响因子：
19.7
通讯作者：
Castellanos, Mario R.
中科院分区：
文献类型：
--
作者：
Zgheib, Mohammad H.;Buchbinder, Shalom S.;Castellanos, Mario R.
目的：在接受心导管检查的女性中，检查乳腺X线检查时发现的乳腺动脉钙化（BAC）是否与冠状动脉造影时发现的冠心病（CHD）相关。材料和方法：在一项机构审查委员会批准的、符合HIPAA的研究中，（平均年龄64.29岁6 +/- 11.97 [标准差]）进行冠状动脉造影的患者被招募、采访并被分为两组：患有（CHD+）和没有（CHD 2）CHD的患者。考虑CHD的严重程度和位置。他们的乳房X光片由一位对CHD状态不知情的乳房成像专家进行审查。适当时进行Student t检验、x 2和多元逻辑回归检验。BAC的存在与CHD的存在和心脏危险因素的存在相关。结果：104例女性CHD患者和68例女性非CHD患者。CHD+组中37名（36%）女性与CHD 2组中20名（29%）女性（P=.40）患有BAC。BAC患者的平均年龄为72岁6 +/- 9.8，明显大于非BAC患者的平均年龄60.4岁6 +/- 11.1（P < .001）。因此，受试者分为65岁以下和65岁及以上。没有相关性存在，尽管事实上，BAC与一些心脏病的危险factors.Conclusion：作者没有观察到BAC和冠状动脉造影检测CHD之间的相关性，即使当CHD的严重程度被认为是。基于这些结果，在使用筛查性乳腺X线摄影检测的BAC来识别CHD患者时应谨慎。
Purpose: To examine, in women who underwent cardiac catheterization, whether breast arterial calcifications ( BACs) seen at screening mammography correlate with coronary heart disease (CHD) seen at coronary angiography.Materials and Methods: In an institutional review board-approved, HIPAA-compliant study, 172 women (mean age, 64.29 years 6 +/- 11.97 [ standard deviation]) who underwent coronary angiography were recruited, interviewed, and assigned to two groups: those with (CHD+) and those without (CHD 2) CHD. The severity and location of the CHD were considered. Their mammograms were reviewed by a breast imaging specialist who was blinded to the CHD status. Student t test, x 2, and multiple logistic regression tests were performed as appropriate. Presence of BAC was noted and correlated with presence of CHD and presence of cardiac risk factors.Results: There were 104 women with and 68 women without CHD. Thirty-seven (36%) women in the CHD+ group versus 20 (29%) in the CHD 2 group (P=.40) had BAC. The mean age of the patients with BAC, 72 years 6 +/- 9.8, was significantly older than the mean age of the patients without BAC, 60.4 years 6 +/- 11.1 (P < .001). Therefore, subjects were divided into those younger than 65 years and those 65 years and older. No correlation existed, despite the fact that BAC was associated with some cardiac risk factors.Conclusion: The authors did not observe a correlation between BAC and coronary angiography-detected CHD, even when CHD severity was considered. On the basis of these results, caution should be exercised when using screening mammography-detected BAC to identify patients with CHD.