The differing influence of several factors on the development of fatty liver with elevation of liver enzymes between genders with metabolic syndrome: A cross-sectional study.
The differing influence of several factors on the development of fatty liver with elevation of liver enzymes between genders with metabolic syndrome: A cross-sectional study.
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DOI：
10.1371/journal.pone.0177925
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Takayama T
中科院分区：
文献类型：
--
作者：
Sogabe M;Okahisa T;Nakasono M;Fukuno H;Miyamoto Y;Okada Y;Okazaki J;Miyoshi J;Tomonari T;Taniguchi T;Goji T;Kitamura S;Miyamoto H;Muguruma N;Takayama T
非酒精性脂肪肝（NAFLD）与肥胖、内脏脂肪、代谢综合征（MS）、生活方式和生活方式相关疾病密切相关。然而，NAFLD、MS和临床背景的患病率在男性和女性之间是不同的。我们进行了一项横断面研究，以检查生活方式相关因素和内脏脂肪对男性和女性MS患者肝酶升高的脂肪肝（FL）的不同影响。我们招募了42，134名接受定期健康检查的人，排除符合排除标准的受试者后，剩余的受试者为2名，我们研究了生活方式相关因素和内脏脂肪对伴有丙氨酸氨基转移酶（ALT）升高的FL的不同影响（本研究中ALT升高定义为ALT水平≥31 IU/l）。FL合并ALT升高的比值比为：WC，1.83（95%置信区间（CI）1.36-2.46）;血脂异常，1.89（95% CI 1.34-2.68）;血红蛋白A1 c，1.36（95% CI 1.00-1.85）;内脏脂肪型MS（V型MS），5.78（95% CI 4.29-7.80）;轻度饮酒者，0.56（95% CI 0.41-0.78）在MS和BMI男性中，2.18（95% CI 1.43-3.33）; WC，1.85（95% CI 1.27-2.70）;舒张压，1.69（95% CI 1.16-2.45）;甘油三酯，2.22（95% CI 1.56-3.17）;糖耐量受损，1.66（95% CI 1.11-2.47）;和V型MS，3.83（95% CI 2.57-5.70）。FL伴ALT升高的患病率和ALT在V-型中显著较高。皮下脂肪型MS的阳性率明显高于皮下脂肪型MS（P < 0.001）。虽然V型MS和WC是MS男性和女性ALT升高FL患病率增加的常见显著预测因素，但MS患者的性别、生活方式相关因素和MS类型应考虑FL伴ALT升高的发展。
Nonalcoholic fatty liver disease (NAFLD) is known to be strongly associated with obesity, visceral fat, metabolic syndrome (MS), lifestyle, and lifestyle-related diseases in both males and females. However, the prevalence of NAFLD, MS, and clinical backgrounds is different between males and females. We conducted a cross-sectional study to examine the differing influence of lifestyle-related factors and visceral fat on fatty liver (FL) with elevation of liver enzymes between males and females with MS. We enrolled 42,134 persons who underwent a regular health check-up, and after excluding subjects who fulfilled excluding criteria, the remaining subjects were 2,110 persons with MS. We examined the differing influence of lifestyle-related factors and visceral fat on FL with elevation of alanine aminotransferase (ALT) (ALT elevation was defined as ALT level of ≥31 IU/l in the present study). The odds rations for FL with ALT elevation were as follows: WC, 1.83 (95% confidence interval (CI) 1.36–2.46); dyslipidemia, 1.89 (95% CI 1.34–2.68); hemoglobin A1c, 1.36 (95% CI 1.00–1.85); visceral fat type MS (V-type MS), 5.78 (95% CI 4.29–7.80); and light drinker, 0.56 (95% CI 0.41–0.78) in males with MS and BMI, 2.18 (95% CI 1.43–3.33); WC, 1.85 (95% CI 1.27–2.70); diastolic blood pressure, 1.69 (95% CI 1.16–2.45); triglyceride, 2.22 (95% CI 1.56–3.17); impaired glucose tolerance, 1.66 (95% CI 1.11–2.47); and V-type MS, 3.83 (95% CI 2.57–5.70) in females with MS. The prevalence of FL with ALT elevation and ALT was significantly higher in V-type MS than in the subcutaneous fat type MS in both males and females with MS (P < 0.001). Although V-type MS and WC is a common significant predictor of an increased prevalence of FL with ALT elevation in both males and females with MS, gender, lifestyle-related factors, and MS type in individuals with MS should be considered for the development of FL with ALT elevation.