The cerebral response to electrical stimuli in the oesophagus is altered by increasing stimulus frequencies
The cerebral response to electrical stimuli in the oesophagus is altered by increasing stimulus frequencies
复制标题
通过增加刺激频率来改变大脑对食道电刺激的反应
DOI：
10.1046/j.1365-2982.1997.d01-27.x
复制
发表时间：
1997
影响因子：
3.5
通讯作者：
G. Tougas
中科院分区：
文献类型：
--
作者：
S. Hollerbach;M. Kamath;D. Fitzpatrick;G. Shine;E. Fallen;A. Upton;G. Tougas
记录大脑诱发反应（EP）可以评估内脏传入通路和肠脑通讯，但最佳刺激参数仍有待确定。本研究确定了电刺激食道以引起 EP 反应的最佳刺激频率。在 13 名健康男性志愿者（24.1±5.9 岁）中，将 5mm 不锈钢电极放置在远端食管中进行电刺激（ES）。根据 10/20 国际系统放置的 21 个头皮电极记录 EP。 ES（15 mA，200 μs）以 24 次刺激的重复系列进行传递。使用伪对数范围（0.1、0.2、0.3、0.5 和 1Hz）随机改变不同系列中的刺激频率。使用每个刺激频率施加两个系列的刺激。在每个刺激频率下使用插值技术创建二维脑地形图。随着刺激频率的增加，在 0.1 Hz 和 1.0 Hz 频率之间观察到 EP 振幅显着且逐渐降低（P1/N2：7.6 ± 1.2 vs 1.4 ± 0.3* μV，N2/P2：17.2 ± 1.7 vs 4.6 ± 0.4* μV，P2/N3：6.9 ± 0.7 vs 4.2 ± 0.5* μV； * = P < 0.05)。此外，随着刺激频率从0.1–1.0 Hz增加，插层P2峰的平均峰值潜伏期显着缩短（P < 0.0005），P3峰也有类似的趋势（P < 0.06）。脑地形图将最大的早期峰值（N1，P1，N2）定位在旁中央皮质区域（C3，Cz，C4），而后期峰值（P2至P3）对称地分布在中央顶叶和颞叶区域（Cz，Pz，T5，T4）。随着刺激频率的增加，最大 EP 振幅的皮质位置没有差异。总之，刺激频率和 EP 幅度之间存在明显的关系，表明随着电刺激频率的增加，大脑自主神经反应迅速衰减。频率增加对峰值潜伏期的影响表明，由于刺激感知的改变，丘脑皮质区域的刺激处理发生了变化。早期 EP 峰值主要源自优势半球的基底结构，而后期峰值则位于中央顶叶皮质区域。
Recording of cerebral evoked responses (EP) allows the assessment of visceral afferent pathways and gut–brain communication, but the optimal stimulation parameters remain to be established. The present study determined the optimal stimulation frequency of electrical stimulation of the oesophagus to elicit EP responses. In 13 healthy male volunteers (24.1 ± 5.9 years), a 5 mm stainless‐steel electrode was placed in the distal oesophagus for electrical stimulation (ES). EP were recorded from 21 scalp electrodes placed according to the 10/20 International system. ES (15 mA, 200 μs) were delivered in repeated series of 24 stimuli. Stimulus frequency was randomly altered in different series using a pseudologarithmic range (0.1, 0.2, 0.3, 0.5, and 1 Hz). Two series of stimuli were applied using each stimulation frequency. Two‐dimensional topographic brain maps were created using interpolation techniques at each stimulation frequency. With increasing stimulus frequency, a significant and progressive decrease of EP amplitudes was observed between frequencies of 0.1 Hz and 1.0 Hz (P1/N2: 7.6 ± 1.2 vs 1.4 ± 0.3* μV, N2/P2: 17.2 ± 1.7 vs 4.6 ± 0.4* μV, P2/N3: 6.9 ± 0.7 vs 4.2 ± 0.5* μV; * = P < 0.05). In addition, there was a significant shortening of the mean peak latency of the intercalated P2 peak (P < 0.0005), with a similar trend for the P3 peak (P < 0.06), with increasing stimulus frequency from 0.1–1.0 Hz. Topographic brain maps localized the maximal early peaks (N1,P1,N2) in the paracentral cortical region (C3, Cz, C4), whereas the later peaks (P2 to P3) were symmetrically spread over the centro‐parietal and temporal regions (Cz, Pz, T5, T4). There was no difference in the cortical location of maximal EP amplitudes with increasing stimulus frequency. In conclusion, there is a clear relationship between stimulus frequency and amplitude of EP, suggesting rapid attenuation of the cerebral autonomic neural responses with increased electrical stimulation frequency. The effect of increased frequency on peak latencies suggests an alteration of stimulus processing in the thalamocortical region due to an altered perception of stimuli. Early EP peaks originate from basal structures of primarily the dominant hemisphere, while later peaks are localized in centroparietal cortical regions.
DOI：
10.1016/0168-5597(93)90033-l
发表时间：
1993-11
期刊：
Electroencephalography and clinical neurophysiology
影响因子：
--
作者：
Vera Loening-Baucke;Thoru Yamada
通讯作者：
Vera Loening-Baucke;Thoru Yamada
内脏输入到脊髓中的感觉通路。
影响因子：
--
作者：
WillisJr,WD
通讯作者：
WillisJr,WD