Landscape genetics and the spatial distribution of chronic wasting disease
Landscape genetics and the spatial distribution of chronic wasting disease
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DOI：
10.1098/rsbl.2007.0523
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发表时间：
2008-02-23
期刊：
影响因子：
3.3
通讯作者：
Filcek, Kristine B.
中科院分区：
文献类型：
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作者：
Blanchong, Julie A.;Samuel, Michael D.;Filcek, Kristine B.
预测野生动物疾病的传播对于确定风险种群、确定监测目标和设计积极主动的管理方案至关重要。我们使用了景观遗传学的方法，以确定景观功能，影响基因流和慢性消耗性疾病（CWD）的分布在威斯康星州白尾鹿。CWD患病率与研究区鹿的遗传分化呈负相关，从鹿在疾病起源的地区（核心区）。遗传分化是最大的，CWD患病率最低，在从核心区分开的地区由威斯康星州河，这表明这条河减少鹿的基因流和可能的疾病传播。根据寄主空间遗传结构，可以确定影响寄主扩散和疾病空间格局的景观特征。景观遗传学可用于根据高危人群与受感染人群的遗传联系预测高危人群，并用于针对疾病监测、控制和预防活动。
Predicting the spread of wildlife disease is critical for identifying populations at risk, targeting surveillance and designing proactive management programmes. We used a landscape genetics approach to identify landscape features that influenced gene flow and the distribution of chronic wasting disease (CWD) in Wisconsin white-tailed deer. CWD prevalence was negatively correlated with genetic differentiation of study area deer from deer in the area of disease origin (core-area). Genetic differentiation was greatest, and CWD prevalence lowest, in areas separated from the core-area by the Wisconsin River, indicating that this river reduced deer gene flow and probably disease spread. Features of the landscape that influence host dispersal and spatial patterns of disease can be identified based on host spatial genetic structure. Landscape genetics may be used to predict high-risk populations based on their genetic connection to infected populations and to target disease surveillance, control and preventative activities.