The impact of L1 retrotransposons on the human genome
The impact of L1 retrotransposons on the human genome
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DOI：
10.1038/ng0598-19
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发表时间：
1998-05-01
期刊：
影响因子：
30.8
通讯作者：
Moran, JV
中科院分区：
文献类型：
--
作者：
Kazazian, HH;Moran, JV
人类的“主要”移动元件，L1反转录转座子，已经成熟为一个生物实体。关于它如何在体内逆转座，它的蛋白质如何作用于其他聚A元件，以及它在塑造人类基因组中的作用程度的知识，应该会在未来几年迅速出现。我们回顾了反转录转座子的影响，以及新的洞察力如何可能导致这些有趣的移动元素的重要实际应用。
The 'master' human mobile element, the L1 retrotransposon, has come of age as a biological entity. Knowledge of how it retrotransposes in vivo, how its proteins act to retrotranspose other poly A elements and the extent of its role in shaping the human genome should emerge rapidly over the next few years. We review the impact of retrotransposons and how new insight is likely to lead to important practical applications for these intriguing mobile elements.