Eccrine anhidrosis due to glutaraldehyde, formaldehyde, and iontophoresis.
Eccrine anhidrosis due to glutaraldehyde, formaldehyde, and iontophoresis.
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戊二醛、甲醛和离子电渗疗法引起的小汗腺无汗症。
DOI：
10.1038/jid.1969.171
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发表时间：
1969
影响因子：
6.5
通讯作者：
H. Maibach
中科院分区：
文献类型：
--
作者：
B. Gordon;H. Maibach
研究了由5%和10%戊二醛和甲醛产生的无汗症，以深入了解作用的解剖部位。剥除角质层在5%浓度下基本消除了无汗症。这表明作用部位涉及角质层的某些部分。在10%浓度下剥离仅部分去除无汗，表明还涉及更深的部位。这种表面作用部位表明可能获得其他醛类，这些醛类可能是有效的止汗剂，但也不具有显著的致敏潜力。使用不同电流密度的自来水的离子电渗疗法也产生显著的无汗。较低毫安的无汗症通过剥离减少50%，而较高毫安的无汗症通过剥离仅部分减少。离子电渗似乎产生表皮损伤。据推测，这会导致异常角化和堵塞的汗管孔。离子电渗疗法是否能为多汗症的治疗提供一种切实可行的方法，目前还有待确定。
Anhidrosis produced by 5 and 10% glutaraldehyde and formaldehyde were studied to gain insight into the anatomic site of action. Stripping the stratum corneum largely removed the anhidrosis in 5% concentration. This suggests that the site of action involved some portion of the stratum corneuin. Stripping in the 10% concentration only partially removed the anhidrosis suggesting that a deeper site was also involved. This superficial site of action suggests the likelihood of obtaining other aldehydes which may be effective anhidrotics without also having significant sensitization potential. lontophoresis with tap water using different current densities also produced a marked anhidrosis. The lower milliamperage anhidrosis was reduced 50% by stripping, whereas the higher milliamperage anhidrosis was only partially reduced by stripping. lontophoresis appears to produce an epidermal injury. It is hypothesized that this results in abnormal keratinization and plugging of sweat duct orifices. It is still to be determined whether iontophoresis offers a practical therapeutic approach to the treat-ment of hyperhidrosis.