RESIDENT CD4(+) ALPHA-BETA T-CELLS OF THE MURINE FEMALE GENITAL-TRACT - A PHENOTYPICALLY DISTINCT T-CELL LINEAGE THAT RAPIDLY PROLIFERATES IN RESPONSE TO SYSTEMIC T-CELL ACTIVATION STIMULI
RESIDENT CD4(+) ALPHA-BETA T-CELLS OF THE MURINE FEMALE GENITAL-TRACT - A PHENOTYPICALLY DISTINCT T-CELL LINEAGE THAT RAPIDLY PROLIFERATES IN RESPONSE TO SYSTEMIC T-CELL ACTIVATION STIMULI
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DOI：
10.1093/intimm/7.11.1763
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发表时间：
1995-11-01
影响因子：
4.4
通讯作者：
LYNCH, RG
中科院分区：
文献类型：
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作者：
IBRAGHIMOV, AR;SACCO, RE;LYNCH, RG
人口的CD4(+)细胞已被确定在小鼠雌性生殖道(燃煤)、燃煤CD4(+)细胞的表型研究证明他们表达CD3,大多数的这些细胞αβ细胞(+)Thy-1(+),大多数Thy-1 CD4 (+) (+) CD4(+)αβ细胞(+)细胞像记忆T细胞CD44的表达基础上,L-selectin CD45RB抗原,绝大多数Thy-1 CD4(+)(+)αβ细胞(+)燃煤细胞CD5(+)和所有B220(-)。全身刺激，包括布氏锥虫感染、注射抗cd3 epsilon或细菌超抗原葡萄球菌肠毒素A或A，导致FGT中CD4（+）细胞的快速积累，超过脾脏和淋巴结（LN）中CD4（+）细胞的积累。FGT CD4（+）细胞的扩张，在表型上与脾和LN CD4(+) T细胞不同，是由于局部增殖而不是循环细胞的涌入。成年nu/nu小鼠的FGT中的CD4（+）群体显著减少，表明其胸腺依赖性。在lpr/lpr小鼠中，FGT中的CD4（+）细胞在同一动物中没有表现出脾脏或LN CD4细胞的特征变化，这些发现表明小鼠FGT的CD4（+）细胞是胸腺依赖性的，但它们构成了一个T细胞谱系，在表型上和功能上可能与其他外周血CD4(+) T细胞群体不同。
A population of CD4(+) cells has been identified in the murine female genital tract (FGT), Phenotypic studies of FGT CD4(+) cells demonstrate that they express CD3 and that the majority of these cells are alpha beta TCR(+)Thy-1(+), Most of the Thy-1(+)CD4(+)CD4(+)alpha beta TCR(+) cells resemble memory T cells based on their expression of CD44, L-selectin and CD45RB antigens, The vast majority of Thy-1(+)CD4(+)alpha beta TCR(+) FGT cells are CD5(+) and all of them are B220(-). Systemic stimuli including infection with Trypanosoma brucei brucei, injection with anti-CD3 epsilon, or bacterial superantigens staphylococcal enterotoxin A or a cause a rapid accumulation of CD4(+) cells in the FGT exceeding that observed for CD4(+) cells in spleen and lymph nodes (LN), Expansion of the FGT CD4(+) cells, which are phenotypically distinct from the splenic and LN CD4(+) T cells, is due to local proliferation rather than an influx of cells from the circulation, The CD4(+) population in the FGT of adult nu/nu mice is dramatically reduced, indicating its thymic dependency, In lpr/lpr mice, FGT CD4 cells do not display changes characteristic of splenic or LN CD4 cells in the same animals, These findings demonstrate that the CD4(+) cells of the murine FGT are thymic dependent, but that they constitute a T cell lineage that phenotypically and, probably functionally, is distinct from other peripheral CD4(+) T cell populations.