Chemically Functionalized Water-Soluble Single-Walled Carbon Nanotubes Modulate Morpho-Functional Characteristics of Astrocytes
Chemically Functionalized Water-Soluble Single-Walled Carbon Nanotubes Modulate Morpho-Functional Characteristics of Astrocytes
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DOI：
10.1021/nl302178s
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发表时间：
2012-09-01
期刊：
影响因子：
10.8
通讯作者：
Parpura, Vladimir
中科院分区：
文献类型：
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作者：
Gottipati, Manoj K.;Kalinina, Irina;Parpura, Vladimir
我们报道了使用化学功能化的水溶性单壁碳纳米管(WS-SWCNTs)来调节星形胶质细胞的形态功能特征。当加入培养液中时，WS-SWCNTs能够使星形胶质细胞变大和星状/成熟，这种变化与胶质纤维酸性蛋白免疫反应性增加有关。因此，WS-SWCNTs在损伤部位可能比之前认为的更有益；通过影响星形胶质细胞，它们可以提供更全面的大脑计算能力的重建。
We report the use of chemically functionalized water-soluble single-walled carbon nanotubes (ws-SWCNTs) for the modulation of morpho-functional characteristics of astrocytes. When added to the culturing medium, ws-SWCNTs were able to make astrocytes larger and stellate/mature, changes associated with the increase in glial fibrillary acidic protein immunoreactivity. Thus, ws-SWCNTs, could have more beneficial effects at the injury site than previously thought; by affecting astrocytes, they could provide for a more comprehensive re-establishment of the brain computational power.