Involvement of microglia in disturbed fear memory regulation: Possible microglial contribution to the pathophysiology of posttraumatic stress disorder
Involvement of microglia in disturbed fear memory regulation: Possible microglial contribution to the pathophysiology of posttraumatic stress disorder
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DOI：
10.1016/j.neuint.2020.104921
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发表时间：
2021-01-01
影响因子：
4.2
通讯作者：
Kato, Takahiro A.
中科院分区：
文献类型：
--
作者：
Enomoto, Shingo;Kato, Takahiro A.
小胶质细胞是大脑中的免疫细胞，通过释放炎症介质和神经营养因子以及吞噬突触成分，在脑炎症和突触可塑性中发挥重要作用。最近的研究表明，外周炎症、大脑免疫改变与人类创伤后应激障碍（PTSD）有关。几项使用巴甫洛夫恐惧条件反射的临床前研究表明，小胶质细胞参与了恐惧记忆失调和恐惧神经网络的改变。由以前的压力经历引起的小胶质细胞启动也可能有影响。本文将介绍目前关于小胶质细胞对创伤后应激障碍（PTSD）的一个基本特征——恐惧记忆紊乱调节的作用。
Microglia, immune cells in the brain, play a crucial role in brain inflammation and synaptic plasticity by releasing inflammatory mediators and neurotrophic factors as well as, phagocytosing synaptic elements. Recent studies have shown peripheral inflammation, immune alteration in the brain are associated with post-traumatic stress disorder (PTSD) in humans. Several preclinical studies using Pavlovian fear conditioning have suggested that microglia are involved in fear memory dysregulation and altered fear neuronal networks. Microglial priming resulting from previous stressful experiences may also have an effect. This review will introduce the current knowledge of microglial contribution to disturbed fear memory regulation, a fundamental feature of PTSD.