Relationship between prevalent oral and cervical human papillomavirus infections in human immunodeficiency virus-positive and -negative women
Relationship between prevalent oral and cervical human papillomavirus infections in human immunodeficiency virus-positive and -negative women
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DOI：
10.1128/jcm.01321-06
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发表时间：
2006-12-01
影响因子：
9.4
通讯作者：
Gillison, Maura
中科院分区：
文献类型：
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作者：
Fakhry, Carole;D'souza, Gypsyamber;Gillison, Maura
人乳头瘤病毒(HPV)是口咽癌和宫颈癌的病原体，但人们对口腔和宫颈HPV感染之间的相互关系知之甚少。因此，我们比较了口腔和宫颈HPV感染的流行率和类型分布，并在女性机构间艾滋病毒研究队列内的一项横断面研究中评估了感染的一致性。口腔冲洗和宫颈阴道冲洗样本同时从172名人类免疫缺陷病毒(HIV)阳性和86名HIV阴性妇女的便利样本中收集。用PGMY09/11L1通用引物聚合酶链式反应检测HPV基因组DNA，反向斑点杂交法检测37种HPV类型和β-珠蛋白。在发现的35种感染宫颈的HPV型中，只有26种也在口腔内发现，口腔感染的HPV型分布与宫颈感染的型分布不同(P<；0.001)。在艾滋病毒阳性(25.2%比76.9%，P<；0.001)和艾滋病毒阴性(9.0%比44.9%，P<；0.001)女性中，口腔HPV感染比宫颈感染更少见。宫颈HPV感染的女性中口腔HPV感染比未感染HPV的女性更常见(25.5%对7.9%，P=0.002)。大多数女性(207人，93.7%)没有同时感染口腔和宫颈，但有这种感染的女性(14人，6.3%)明显多于偶然预期的数量(P=0.0002)。因此，口腔和颈部HPV感染的蓄水池可能不是完全独立的。
Human papillomavirus (HPV) is an etiologic agent for both oropharyngeal and cervical cancers, yet little is known about the interrelationship between oral and cervical HPV infections. Therefore, we compared the prevalences and type distributions of oral and cervical HPV infections and evaluated infection concordance in a cross-sectional study within the Women's Interagency HIV Study cohort. Oral rinse and cervical-vaginal lavage samples were concurrently collected from a convenience sample of 172 human immunodeficiency virus (HIV)-positive and 86 HIV-negative women. HPV genomic DNA was detected by PGMY09/11 L1 consensus primer PCR and type specified by reverse line blot hybridization for 37 HPV types and beta-globin. Only 26 of the 35 HPV types found to infect the cervix were also found within the oral cavity, and the, type distribution for oral HPV infections appeared distinct from that for cervical infections (P < 0.001). Oral HPV infections were less common than cervical infections for both HIV-positive (25.2% versus 76.9%, P < 0.001) and HIV-negative (9.0% versus 44.9%, P < 0.001) women. Oral HPV infections were more common among women with a cervical HPV infection than those without a cervical HPV infection (25.5% versus 7.9%, P = 0.002). The majority of women (207; 93.7%) did not have simultaneous oral and cervical infections by the same HPV type; however, the number of women who did (14; 6.3%) was significantly greater than would be expected by chance (P = 0.0002). Therefore, the oral and cervical reservoirs for HPV infection are likely not entirely independent of one another.