Sympatho-inhibitory action of endogenous adrenomedullin through inhibition of oxidative stress in the brain
Sympatho-inhibitory action of endogenous adrenomedullin through inhibition of oxidative stress in the brain
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DOI：
10.1161/01.hyp.0000165690.85505.37
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发表时间：
2005-06-01
期刊：
影响因子：
8.3
通讯作者：
Fujita, T
中科院分区：
文献类型：
--
作者：
Fujita, M;Kuwaki, T;Fujita, T
中枢交感神经激活是高血压的可能机制之一，活性氧可能在其中发挥作用。因此，我们检查了肾上腺髓质素（一种抗氧化肽）是否通过交感调节作用参与动脉压的中枢调节。肾上腺髓质素基因敲除小鼠被喂食高盐饮食 4 周，以刺激肾上腺髓质素的产生。在野生型同窝小鼠中，脑肾上腺髓质素含量随着盐负荷的增加而显着增加，但在基因敲除小鼠中则不然。脑室内高渗盐水以剂量依赖性方式增加动脉压和交感神经活动。在正常盐饮食下，高渗盐水诱导的反应在基因敲除小鼠和野生型小鼠之间没有显着差异；然而，对于高盐饮食，基因敲除小鼠的反应明显高于野生型同窝小鼠（动脉压：35.3+/-5.7% 对比 20.1+/-2.1%，P
Central sympathetic activation is one of the possible mechanisms underlying hypertension, in which reactive oxygen species may play a role. Thus, we examined whether adrenomedullin, an antioxidant peptide, is involved in the central regulation of arterial pressure through sympatho-modulatory action. Adrenomedullin knockout mice were fed with high-salt diet for 4 weeks to stimulate adrenomedullin production. In the wild-type littermates, brain adrenomedullin content was significantly increased with salt loading, but not in the knockout mice. Intracerebroventricular hyperosmotic saline increased arterial pressure and sympathetic nerve activity in a dose-dependent fashion. With the normal salt diet, the hyperosmotic saline-induced response did not significantly differ between the knockout and wild-type mice; with the high-salt diet, however, the response was significantly greater in the knockout mice than in wild-type littermates (arterial pressure: 35.3+/-5.7% versus 20.1+/-2.1%, P