Perinatal risk factors for childhood type 1 diabetes in Europe - The EURODIAB substudy 2 study group
Perinatal risk factors for childhood type 1 diabetes in Europe - The EURODIAB substudy 2 study group
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DOI：
10.2337/diacare.22.10.1698
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发表时间：
1999-10-01
期刊：
影响因子：
16.2
通讯作者：
Soltesz, G
中科院分区：
文献类型：
--
作者：
Dahlquist, GG;Patterson, C;Soltesz, G
目的-探讨围产期因素是否与儿童1型糖尿病的发展有关。研究设计和方法-我们研究了来自欧洲7个研究中心的892例儿童1型糖尿病患者的医院记录，并与2,291例以人群为基础的对照组进行了比较。母亲先兆子痫、新生儿呼吸道疾病和血型不合引起的黄疸是1型糖尿病的重要危险因素，而头胎、出生体重低或出生身长短则具有保护作用。剖宫产分娩和新生儿感染性疾病与1型糖尿病的风险在这项研究中没有显着相关。血型不合（ABO和Rh因子）的相关性最强，比值比（OR）为2.96（95%CI 1.88-4.65）。ABO血型不合（OR = 3.92）比Rh血型不合（OR = 1.62）更常见，也是一个更强的危险因素。ABO血型不合的影响是独立的治疗效果在逻辑回归analysis.CONCLUSIONS -不同的围产期事件与1型糖尿病的风险增加。母子血型不合的影响是强烈的，表明一个真正的影响，必须进一步探讨。
OBJECTIVE - To explore whether perinatal factors are associated with the development of childhood type 1 diabetes.RESEARCH DESIGN AND METHODS - We studied hospital records from 892 cases of childhood type 1 diabetes compared with 2,291 population-based control subjects in seven study centers in Europe.RESULTS - In a pooled analysis incorporating stratification by center, we confirmed the previous findings that older maternal age, maternal preeclampsia, neonatal respiratory disease, and jaundice caused by blood group incompatibility are significant risk factors for type 1 diabetes, whereas being a firstborn child, having a low birth weight, or having a short birth length were protective. Cesarean section delivery and neonatal infectious diseases were not significantly associated with the risk of type 1 diabetes in this study. The strongest association was found for blood group incompatibility (ABO and Rh factor) with an odds ratio (OR) of 2.96 (95% CI 1.88-4.65). ABO incompatibility (OR = 3.92) was a more common and also a stronger risk factor than Rh incompatibility (OR = 1.62). The effect of ABO blood group incompatibility was independent of treatment effects in logistical regression analysis.CONCLUSIONS - Different perinatal events are associated with an increased risk of type 1 diabetes. The effect of maternal-child blood group incompatibility is strong and indicates a true effect that must be further explored.