Retinoid metabolism during development of liver cirrhosis
Retinoid metabolism during development of liver cirrhosis
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DOI：
10.1016/j.abb.2005.09.008
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发表时间：
2005-11-15
影响因子：
3.9
通讯作者：
Balasubramanian, KA
中科院分区：
文献类型：
--
作者：
Natarajan, SK;Thomas, S;Balasubramanian, KA
类维生素A代谢的变化已在肝硬化中被记录。然而，在肝硬化发展过程中，这种维生素在循环和肝脏之间的水平动态变化还不清楚。本研究的目的是测量类维生素A在肝脏和循环中的平行，在四氯化碳和硫代乙酰胺诱导的肝硬化的发展过程中和之后。通过HPLC测量类维生素A水平。开始给药后一个月内，四氯化碳或硫代乙酰胺给药大鼠的肝脏中的视黄醇和总视黄醇减少，而视黄酸增加。在肝脏中，参与类维生素A代谢的酶如视黄醇氧化酶、视黄醇脱氢酶和视黄醇还原酶的活性降低。与此同时，血清中的视黄醇和视黄醇水平升高，而视黄酸降低。这项研究表明，在肝硬化的发展过程中，循环和肝脏之间存在维甲酸代谢物的相互转移。(c)2005年爱思唯尔公司All rights reserved.
The changes in retinoid metabolism have been documented in liver cirrhosis. However, the dynamic alterations in levels of this vitamin between circulation and liver during development of the liver cirrhosis are not well understood. The aim of this study was to measure retinoids in the liver and circulation in parallel, during and after development of cirrhosis induced by carbon tetrachloride and thioacetamide. Retinoid levels were measured by HPLC. A decrease in retinaldehyde and total retinol, together with an increase in retinoic acid was evident in liver from both carbon tetrachloride or thioacetamide treated rats within a month after initiation of treatment. Activity of enzymes involved in retinoid metabolism such as retinaldehyde oxidase, retinaldehyde dehydrogenase, and retinaldehyde reductase were decreased in the liver. In parallel, levels of retinol and retinaldehyde in the serum were increased while retinoic acid was decreased. This study indicates that during development of cirrhosis, there is reciprocal transfer of retinoid metabolites between the circulation and the liver. (c) 2005 Elsevier Inc. All rights reserved.