Remotely tunable microfluidic platform driven by nanomaterial-mediated on-demand photothermal pumping
Remotely tunable microfluidic platform driven by nanomaterial-mediated on-demand photothermal pumping
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DOI：
10.1039/d0lc00317d
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发表时间：
2020-06-21
期刊：
影响因子：
6.1
通讯作者：
Li, XiuJun
中科院分区：
文献类型：
--
作者：
Fu, Guanglei;Zhou, Wan;Li, XiuJun
按需微流体泵和无仪器读数方法的需求仍然是微流控技术发展的主要挑战。本文利用片上纳米材料介导的光热效应作为新型的、可远程调谐的微流控驱动力，研制了一种新型的微流控平台--按需光热微流控泵送平台。光热微流控泵的性能可以通过调节辐照参数进行远程调节，而无需改变芯片上的参数或更换酶或其他试剂。与氧化石墨烯相比，普鲁士蓝纳米粒子具有更高的光热转换效率，作为模型光热剂进行了概念验证。芯片上的泵浦距离与辐照时间和纳米材料的浓度呈线性关系。光热微流控泵已被证明应用于多种物质的芯片上传输，如金纳米颗粒，以及不使用专门仪器的癌症生物标志物的可视化定量条形图检测。在使用激光指示器进行非接触照射时，强大的片上纳米材料介导的光热效应可以作为PMMA/PDMS混合条形图芯片中的坚固和远程可调的微流体泵，以视觉定量读出的方式驱动墨条。这是关于光热微流控泵送平台的首次报道，它在各种微流控领域具有巨大的应用潜力。
The requirement of on-demand microfluidic pumps and instrument-free readout methods remains a major challenge for the development of microfluidics. Herein, a new type of microfluidic platform, an on-demand photothermal microfluidic pumping platform, has been developed using an on-chip nanomaterial-mediated photothermal effect as novel and remotely tunable microfluidic driving force. The photothermal microfluidic pumping performance can be adjusted remotely by tuning the irradiation parameters, without changing on-chip parameters or replacing enzymes or other reagents. In contrast to graphene oxide, Prussian blue nanoparticles with higher photothermal conversion efficiency were used as the model photothermal agent to demonstrate the proof of concept. The on-chip pumping distance is linearly correlated with both the irradiation time and the nanomaterial concentration. The applications of photothermal microfluidic pumping have been demonstrated in multiplexed on-chip transport of substances, such as gold nanoparticles, and visual quantitative bar-chart detection of cancer biomarkers without using specialized instruments. Upon contact-free irradiation using a laser pointer, a strong on-chip nanomaterial-mediated photothermal effect can serve as a robust and remotely tunable microfluidic pump in a PMMA/PDMS hybrid bar-chart chip to drive ink bars in a visual quantitative readout fashion. This is the first report on a photothermal microfluidic pumping platform, which has great potential for various microfluidic applications.