Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond).
Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond).
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DOI：
10.1111/bph.14196
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发表时间：
2019-04
影响因子：
7.3
通讯作者：
Warner TD
中科院分区：
文献类型：
--
作者：
Crescente M;Menke L;Chan MV;Armstrong PC;Warner TD
血小板是血栓形成和止血的重要参与者，其功能由血液和血管壁中的介质调节。其中，类二十烷酸可以刺激和抑制血小板反应性。血小板环氧合酶（考克斯）-1生成血栓烷（TX）A2是刺激血小板聚集的主要前列腺素;其作用被前列环素（血管考克斯的产物）抵消。前列腺素（PG）D2，PGE 2和12-羟基二十碳四烯酸（HETE），或15-HETE，是血小板活性的其他前列腺素类调节剂，但有些也在致癌作用中发挥作用。阿司匹林可永久抑制血小板考克斯-1，这是其抗血栓形成和抗癌作用的基础。虽然越来越多地鼓励使用阿司匹林作为抗癌药物，但目前仍在争论是否继续使用P2 Y12受体拮抗剂治疗心血管疾病。阿司匹林不仅抑制TXA 2，而且还阻止已知和未知的抗血小板类花生酸途径的合成，可能降低双重抗血小板治疗的疗效。这篇文章是1982年诺贝尔奖35年后关于类花生酸的主题部分的一部分：我们现在在哪里？要查看本节中的其他文章，请访问http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.8/issuetoc
Platelets are important players in thrombosis and haemostasis with their function being modulated by mediators in the blood and the vascular wall. Among these, eicosanoids can both stimulate and inhibit platelet reactivity. Platelet Cyclooxygenase (COX)‐1‐generated Thromboxane (TX)A2 is the primary prostanoid that stimulates platelet aggregation; its action is counter‐balanced by prostacyclin, a product of vascular COX. Prostaglandin (PG)D2, PGE2 and 12‐hydroxyeicosatraenoic acid (HETE), or 15‐HETE, are other prostanoid modulators of platelet activity, but some also play a role in carcinogenesis. Aspirin permanently inhibits platelet COX‐1, underlying its anti‐thrombotic and anti‐cancer action. While the use of aspirin as an anti‐cancer drug is increasingly encouraged, its continued use in addition to P2Y12 receptor antagonists for the treatment of cardiovascular diseases is currently debated. Aspirin not only suppresses TXA2 but also prevents the synthesis of both known and unknown antiplatelet eicosanoid pathways, potentially lessening the efficacy of dual antiplatelet therapies. This article is part of a themed section on Eicosanoids 35 years from the 1982 Nobel: where are we now? To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.8/issuetoc
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影响因子：
168.9
作者：
Burn, John;Gerdes, Anne-Marie;Macrae, Finlay;Mecklin, Jukka-Pekka;Moeslein, Gabriela;Olschwang, Sylviane;Eccles, Diane;Evans, D. Gareth;Maher, Eamonn R.;Bertario, Lucio;Bisgaard, Marie-Luise;Dunlop, Malcolm G.;Ho, Judy W. C.;Hodgson, Shirley V.;Lindblom, Annika;Lubinski, Jan;Morrison, Patrick J.;Murday, Victoria;Ramesar, Raj;Side, Lucy;Scott, Rodney J.;Thomas, Huw J. W.;Vasen, Hans F.;Barker, Gail;Crawford, Gillian;Elliott, Faye;Movahedi, Mohammad;Pylvanainen, Kirsi;Wijnen, Juul T.;Fodde, Riccardo;Lynch, Henry T.;Mathers, John C.;Bishop, D. Timothy
通讯作者：
Bishop, D. Timothy
影响因子：
158.5
作者：
Bertagnolli, Monica M.;Eagle, Craig J.;Hawk, Ernest T.
通讯作者：
Hawk, Ernest T.
影响因子：
2.8
作者：
Bhatt, Deepak L.
通讯作者：
Bhatt, Deepak L.
影响因子：
4.8
作者：
Bolego, Chiara;Buccellati, Carola;Sala, Angelo
通讯作者：
Sala, Angelo
影响因子：
2.9
作者：
ARMSTRONG, RA;JONES, RL;WILSON, NH
通讯作者：
WILSON, NH