Vitamin E: beyond antioxidant function.
Vitamin E: beyond antioxidant function.
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DOI：
10.1093/ajcn/62.6.1501s
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发表时间：
1995-12
期刊：
影响因子：
--
通讯作者：
M. Traber;L. Packer
中科院分区：
文献类型：
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作者：
M. Traber;L. Packer
维生素E是一种有效的过氧自由基清除剂，是一种链断裂抗氧化剂，可防止生物膜中自由基损伤的传播。我们认为，在细胞代谢和信号转导的维生素E可能有一个结构特异性的作用，除了其抗氧化功能的潜在网站的证据。生育酚结合蛋白在维生素E的细胞运输中的作用，特别是将RRR-alpha-生育酚纳入新生脂蛋白，并将RRR-alpha-生育酚传递到细胞核。我们讨论了维生素E在抑制和增强花生四烯酸代谢中的作用。还评价了维生素E在细胞增殖和分化过程中的相互作用。维生素E的这些功能提出了新的问题，并代表了具有生理意义的细胞调节研究的新的和令人兴奋的领域。
Vitamin E, a potent peroxyl radical scavenger, is a chain-breaking antioxidant that prevents the propagation of free radical damage in biological membranes. We consider the evidence for potential sites in cellular metabolism and signal transduction where vitamin E may have a structure-specific role in addition to its antioxidant function. The roles of tocopherol-binding proteins in cellular trafficking of vitamin E, especially the incorporation of RRR-alpha-tocopherol into nascent lipoproteins, and the delivery of RRR-alpha-tocopherol to the nucleus are considered. We discuss the functions of vitamin E both in the inhibition and potentiation of arachidonic acid metabolism. The interactions of vitamin E during cell proliferation and differentiation are also evaluated. These functions of vitamin E raise new questions and represent new and exciting areas for research in cell regulation with physiologic implications.