Local regulation of striatal dopamine: A diversity of circuit mechanisms for a diversity of behavioral functions?
Local regulation of striatal dopamine: A diversity of circuit mechanisms for a diversity of behavioral functions?
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DOI：
10.1016/j.conb.2024.102839
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发表时间：
2024-02
影响因子：
5.7
通讯作者：
Elizabeth N. Holly;Jamie Galanaugh;M. Fuccillo
中科院分区：
文献类型：
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作者：
Elizabeth N. Holly;Jamie Galanaugh;M. Fuccillo
纹状体多巴胺支配广泛的行为功能，但局部多巴胺浓度可以与躯体活动分离。在这里，我们讨论了多巴胺的不同角色的行为可能是由局部电路机制塑造多巴胺的释放。我们首先看看历史和最近的工作表明，纹状体电路与多巴胺能终端相互作用，要么启动多巴胺的释放或调节多巴胺的释放启动的尖峰在中脑多巴胺神经元，特别注意GABA能和胆碱能局部电路机制。然后，我们讨论了一些第一次在纹状体乙酰胆碱-多巴胺相互作用的活体研究，并广泛讨论了必要的未来工作，了解中脑与纹状体多巴胺调节的作用。
Striatal dopamine governs a wide range of behavioral functions, yet local dopamine concentrations can be dissociated from somatic activity. Here, we discuss how dopamine's diverse roles in behavior may be driven by local circuit mechanisms shaping dopamine release. We first look at historical and recent work demonstrating that striatal circuits interact with dopaminergic terminals to either initiate the release of dopamine or modulate the release of dopamine initiated by spiking in midbrain dopamine neurons, with particular attention to GABAergic and cholinergic local circuit mechanisms. Then we discuss some of the firstin vivostudies of acetylcholine-dopamine interactions in striatum and broadly discuss necessary future work in understanding the roles of midbrain versus striatal dopamine regulation.