Unified Syntheses of Cavicularin and Riccardin C: Addressing the Synthesis of an Arene Adopting a Boat Configuration
Unified Syntheses of Cavicularin and Riccardin C: Addressing the Synthesis of an Arene Adopting a Boat Configuration
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DOI：
10.1002/chem.201101550
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发表时间：
2011-09-01
影响因子：
4.3
通讯作者：
Harrowven, David C.
中科院分区：
文献类型：
--
作者：
Kostiuk, Sarah L.;Woodcock, Timothy;Harrowven, David C.
报道了天然产物Cavicularin（十步）和Riccardin C（七步）的简明合成方法。新的合成路线的主要特点是一个收敛的策略，组装无环前体和一系列的区域选择性还原和卤化步骤，以促进维蒂希大环化和transannular环收缩反应。
Concise syntheses of the natural products cavicularin (ten steps) and riccardin C (seven steps) are reported. Key features of the new synthetic route are a convergent strategy to assemble acyclic precursors and a sequence of regioselective reduction and halogenation steps to facilitate Wittig macrocyclisation and transannular ring contraction reactions.