Lipid peroxidation and total antioxidant status in patients with breast cancer
Lipid peroxidation and total antioxidant status in patients with breast cancer
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DOI：
10.1027/cbf.1308
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发表时间：
2007-07-01
影响因子：
3.6
通讯作者：
Torun, Meral
中科院分区：
文献类型：
--
作者：
Sener, Derya Erten;Gonenc, Aymelek;Torun, Meral
氧化应激被认为与所有癌症的病理生理有关。本研究的目的是通过评估乳腺癌患者的血清总抗氧化能力（TAC）和脂质过氧化产物丙二醛（MDA）和脂质过氧化氢水平来检测氧化应激和抗氧化状态，并探讨这些参数、氧化应激与血脂和脂蛋白之间的关系。本研究测定了56例不同临床分期乳腺癌患者和18例健康女性的血清TAC、MDA、脂质过氧化氢、hdl -胆固醇、vldl -胆固醇、ldl -胆固醇、总胆固醇、三酰甘油（TAG）、白蛋白和尿酸水平。乳腺癌患者TAC水平明显低于对照组（分别为2.01 +/- 0.01 mmol/l和2.07 +/- 0.03 mmol/l, p < 0.05）。患者血清MDA水平高于对照组（分别为3.64 +/- 0.25 μ M和2.72 +/- 0.22 μ M, p < 0.05）。患者与对照组脂质过氧化氢水平差异无统计学意义（分别为0.33 +/- 0.05 mu M和0.32 +/- 0.01 mu M, p < 0.05）。这些数据表明较低的TAC和较高的MDA水平即氧化应激的增加可能与乳腺癌有关。版权所有(C) 2006 John Wiley & Sons, Ltd。
Oxidative stress is considered to be involved in the pathophysiology of all cancers. The aim of this study is to examine oxidative stress and antioxidant status in patients with breast cancer by evaluation of the serum levels of total antioxidant capacity (TAC) and lipid peroxidation products as malondialdehyde (MDA) and lipid hydroperoxide and to investigate the relationship between these parameters, oxidative stress and serum lipids and lipoproteins. In our study, serum TAC, MDA, lipid hydroperoxide, HDL-cholesterol, VLDL-cholesterol, LDL-cholesterol, total cholesterol, triacylglycerol (TAG), albumin and uric acid levels of 56-breast cancer patients in different clinical stages and 18 healthy women were determined. Significantly lower-levels of TAC were detected in patients with breast cancer in comparison to controls (2.01 +/- 0.01 mmol/l and 2.07 +/- 0.03 mmol/l, respectively, p < 0.05). Serum MDA levels of the patients were higher compared to the controls (3.64 +/- 0.25 mu M and 2.72 +/- 0.22 mu M, respectively, p < 0.05). No significant difference between lipid hydroperoxide levels of patients and controls was found (0.33 +/- 0.05 mu M and 0.32 +/- 0.01 mu M, respectively, p > 0.05). These data show that lower TAC and higher MDA levels i.e. increased oxidative stress may be related to breast cancer. Copyright (C) 2006 John Wiley & Sons, Ltd.