Effect of estrogen-serotonin interactions on mood and cognition.
Effect of estrogen-serotonin interactions on mood and cognition.
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DOI：
10.1177/1534582305277152
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发表时间：
2005-03-01
期刊：
影响因子：
--
通讯作者：
Epperson, C Neill
中科院分区：
文献类型：
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作者：
Amin, Zenab;Canli, Turhan;Epperson, C Neill
神经递质血清素和卵巢类固醇雌激素都与情绪和认知的调节有关。虽然雌激素和血清素之间的重要功能相互作用是公认的，但它们之间关系的性质尚未完全阐明。使用卵巢切除动物的研究已经确定了雌激素诱导的5-羟色胺传输，结合和代谢的变化，涉及情感和认知的调节的大脑区域。对人类的研究，特别是对接受雌激素治疗的绝经期妇女的研究，为这些发现提供了一些支持，并确定了情绪或认知变化伴随着血清素功能和激素状态改变的情况。然而，很明显，需要进一步的研究来了解雌激素和血清素之间相互作用的神经过程。通过回顾有关雌激素和血清素对情绪和认知影响的动物和人类数据，作者旨在更好地定义它们之间的关系，并强调进一步研究的领域。
Both the neurotransmitter serotonin and the ovarian steroid estrogen have been implicated in the modulation of mood and cognition. Although significant functional interactions between estrogen and serotonin are acknowledged, the nature of their relationship has not been fully elucidated. Research using ovariectomized animals has identified estrogen-induced changes in serotonin transmission, binding, and metabolism in brain regions implicated in the regulation of affect and cognition. Studies in humans, particularly of menopausal women undergoing estrogen treatment, have provided some support for these findings and identified instances in which change in mood or cognition is accompanied by alterations in serotonin function and hormonal status. However, it is apparent that further research is required to understand the neural processes involved in the interplay between estrogen and serotonin. By reviewing animal and human data regarding estrogen and serotonin's effects on mood and cognition, the authors aim to better define their relationship and highlight areas for further research.