A general role of hedgehog in the regulation of proliferation
A general role of hedgehog in the regulation of proliferation
复制标题
DOI：
10.4161/cc.6.2.3745
复制
发表时间：
2007-01-15
期刊：
影响因子：
4.3
通讯作者：
Perron, Muriel
中科院分区：
文献类型：
--
作者：
Agathocleous, Michalis;Locker, Morgane;Perron, Muriel
Hedgehog(HH)途径调节多种组织的增殖，但其对细胞周期的具体作用尚不清楚。特别是在视网膜增殖过程中，HH的作用一直存在争议，各种研究表明HH对增殖有刺激或抑制作用。我们最近的数据提供了一个潜在的机制，调和了这些不同的观点。我们发现，视网膜中的HH信号加速了细胞周期的G(1)和G(2)期，然后将这些快速分裂的细胞过早地推出了细胞周期。根据这一证据和其他证据，我们认为HH将静止的视网膜干细胞转化为更接近细胞周期退出和分化的快周期瞬时扩增前体细胞。我们认为，这可能是HH在神经系统和其他组织中的普遍作用。HH在细胞周期动力学和细胞周期退出中的作用可能对肿瘤的发生和脑的进化有一定的意义。
The Hedgehog (Hh) pathway regulates proliferation in a variety of tissues, however its specific effects on the cell cycle are unclear. During retinal proliferation in particular, the role of Hh has been controversial, with studies variably suggesting a stimulatory or an inhibitory effect on proliferation. Our recent data provide an underlying mechanism, which reconciles these different views. We showed that Hh signaling in the retina accelerates the G(1) and G(2) phases of the cell cycle and then pushes these rapidly dividing cells out of the cell cycle prematurely. From this and other evidence, we propose that Hh converts quiescent retinal stem cells into fast-cycling transient amplifying progenitors that are closer to cell cycle exit and differentiation. This is, we suggest, likely to be a general role of Hh in the nervous system and other tissues. This function of Hh in cell cycle kinetics and cell cycle exit may have implications for tumorigenesis and brain evolution.