Pharmacological validation of a novel home cage activity counter in mice
Pharmacological validation of a novel home cage activity counter in mice
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DOI：
10.1016/j.jneumeth.2007.01.008
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发表时间：
2007-05-15
影响因子：
3
通讯作者：
Schmidt, M. V.
中科院分区：
文献类型：
--
作者：
Ganea, K.;Liebl, C.;Schmidt, M. V.
许多啮齿类动物的行为测试都是基于受试组之间动物的基本运动活动相似的前提。因此，对基本家庭笼子活动的测量是一个基本参数，应该包括在所有使用焦虑或认知测试的研究中。目前可用于评估家庭笼子移动的系统通常复杂且昂贵。在这里，我们描述并验证了一种新颖、简单和经济高效的装置，用于评估啮齿类动物的基本家庭笼子活动。使用家笼活动计数器可以可靠地获得昼夜暗-光活动模式。此外，该仪器还能可靠、灵敏地检测到由新奇事物或药物治疗引起的运动变化。因此，本文提出的家笼活动计数器可用于基础家笼活动的测量。(C)2007 Elsevier B.V.保留所有权利。
Many behavioural tests in rodents are based on the premise that basal locomotor activity of the animals is similar between the tested groups. The measurement of basal home cage activity is therefore an essential parameter, that should be included in all studies which employ tests of anxiety or cognition. Currently available systems for the assessment of home cage locomotion are often complex and expensive. Here we describe and validate a novel, simple and cost-efficient apparatus for the assessment of basic home cage locomotor activity in rodents. Circadian dark-light activity patterns can be reliably obtained with the home cage activity counter. Furthermore, changes in locomotion induced by novelty or pharmacological treatment were reliably and sensitively detected by the apparatus. Thus, the here presented home cage activity counter can be used for the measurement of basal home cage locomotor activity. (C) 2007 Elsevier B.V. All rights reserved.