Mitotic regulation of SREBP and ATF6 by separation of the Golgi and ER
Mitotic regulation of SREBP and ATF6 by separation of the Golgi and ER
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DOI：
10.4161/cc.7.14.6327
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发表时间：
2008-07-15
期刊：
影响因子：
4.3
通讯作者：
Seemann, Joachim
中科院分区：
文献类型：
--
作者：
Bartz, Rene;Seemann, Joachim
高尔基体的高度组织化结构在有丝分裂过程中受到损害。高尔基体池分解并形成小泡，然后将其分配到子细胞中。在这里，我们分析了SREBP和ATF6的命运，这两个关键的转录因子的甾醇生物合成和未折叠的蛋白质反应，分别。在间期，两种转录因子的前体在ER中是沉默的，但在激活信号SREBP和ATF 6移动到高尔基体时，它们被S1P和S2P的蛋白水解裂解激活。由于ER和高尔基体之间的空间分离是调节激活的基础，我们研究了有丝分裂是否足以触发激活。我们发现，ER和高尔基体的严格区室化在有丝分裂过程中维持，以抑制SREBP和ATF 6的激活。
The highly organized structure of the Golgi apparatus becomes compromised during mitosis. The Golgi cisternae unstack and form vesicles, which are then partitioned into the daughter cells. Here, we analyzed the fate of the SREBP and ATF6, two key transcription factors of sterol biogenesis and the unfolded protein response, respectively. During interphase the precursors of both transcription factors are silent in the ER, but upon activation signals SREBP and ATF6 move to the Golgi where they are activated by proteolytic cleavage by S1P and S2P. Since the spatial separation between the ER and the Golgi is the basis for the regulated activation, we investigated whether mitosis is sufficient to trigger activation. We found that the strict compartmentalization of the ER and the Golgi is maintained during mitosis to inhibit the activation of SREBP and ATF6.