THE RETARDATION OF AGING IN MICE BY DIETARY RESTRICTION - LONGEVITY, CANCER, IMMUNITY AND LIFETIME ENERGY-INTAKE
THE RETARDATION OF AGING IN MICE BY DIETARY RESTRICTION - LONGEVITY, CANCER, IMMUNITY AND LIFETIME ENERGY-INTAKE
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DOI：
10.1093/jn/116.4.641
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发表时间：
1986-04-01
影响因子：
4.2
通讯作者：
GUTHRIE, D
中科院分区：
文献类型：
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作者：
WEINDRUCH, R;WALFORD, RL;GUTHRIE, D
我们试图阐明饮食限制（无营养不良的营养不足）对衰老的影响。来自长寿品系的雌性小鼠在断奶后以六种方式之一喂养：组(1)无限制的非纯化饮食；(2) 85千卡/周的纯净饮食(约为1。25%的限制);(3) 50千卡/周的限制纯化饮食，富含蛋白质、维生素和矿物质，以提供与第二组几乎相等的这些必需物质的摄入量。55%的限制);(4)按第3组，但在断奶前也有限制；(5) 50千卡/周的富含维生素和矿物质的饮食，但随着寿命的延长蛋白质摄入量逐渐减少；(6)第3组和第4组饲喂40千卡/周的日粮。65%的限制)。3 ~ 6组小鼠的平均寿命和最长寿命比1组增加35 ~ 65%，比2组增加20 ~ 40%。第6组的小鼠寿命最长。第6组中寿命最长的10%的小鼠平均寿命为53.0岁，据我们所知，这超过了任何品系的任何小鼠的报告值。对肿瘤类型和t淋巴细胞增殖随年龄下降的有益影响在第6组最为显著。在3-5组中，成年体重与寿命呈显著正相关，这表明代谢效率的提高可能与限制性小鼠的寿命有关。3 ~ 6组小鼠均饲喂。在整个生命周期中，每克老鼠比第二组的老鼠多摄入30%的卡路里。这些发现显示了饮食限制具有深远的抗衰老作用，并为优化饮食限制制度提供了新的信息。
We sought to clarify the impact of dietary restriction (undernutrition without malnutrition) on aging. Female mice from a long-lived strain were fed after weaning in one of six ways: group (1) a nonpurified diet ad libitum; (2) 85 kcal/wk of a purified diet (.apprx. 25% restriction); (3) 50 kcal/wk of a restricted purified diet enriched in protein, vitamin and mineral content to provide nearly equal intakes of these essentials as in group 2 (.apprx. 55% restriction); (4) as per group 3, but also restricted before weaning; (5) 50 kcal/wk of a vitamin- and mineral-enriched diet but with protein intake gradually reduced over the life span; (6) 40 kcal/wk of the diet fed to groups 3 and 4 (.apprx. 65% restriction). Mice from groups 3-6 exhibited mean and maximal life spans 35-65% greater than for group 1 and 20-40% greater than for group 2. Mice from group 6 lived longest of all. The longest lived 10% of mice from group 6 averaged 53.0 mo. which, to our knowledge, exceeds reported values for any mice of any strain. Beneficial influences on tumor patterns and on declines with age in T-lymphocyte proliferation were most striking in group 6. Significant positive correlations beween adult body weight and longevity occurred in groups 3-5 suggesting that increased metabolic efficiency may be related to longevity in restricted mice. Mice from groups 3-6 ate .apprx. 30% more calories per gram of mouse over the life span than did mice from group 2. These findings show the profound anti-aging effects of dietary restriction and provide new information for optimizing restriction regimes.