Overlapping and diverse distribution of Na-K ATPase isozymes in neurons and glia.
Overlapping and diverse distribution of Na-K ATPase isozymes in neurons and glia.
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DOI：
10.1139/y92-269
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发表时间：
1992
影响因子：
2.1
通讯作者：
K. Sweadner
中科院分区：
文献类型：
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作者：
K. Sweadner
Na-K ATP酶是质膜酶，其催化K+的主动摄取和Na+的排出，从而在细胞内外之间建立离子浓度梯度。它消耗了大脑所用能量的很大一部分。这种酶存在于神经元和神经胶质中。离子流和膜相关ATP酶活性特性的研究表明，在中枢神经系统中存在不止一种功能类型的Na-K ATP酶。分子克隆已经证明，有三个不同的基因编码催化（α）亚基和至少两个基因编码糖蛋白（β）亚基;所有在大脑中表达。本文综述了Na-K ATP酶同工酶的分布和性质。神经元和神经胶质细胞可以以细胞特异性方式表达不同的亚型。
The Na-K ATPase is the plasma membrane enzyme that catalyzes the active uptake of K+ and extrusion of Na+, thereby establishing ion concentration gradients between the inside and outside of the cell. It consumes a large fraction of the energy used in the brain. The enzyme is present in both neurons and glia. Studies of ion flux and of the properties of membrane-associated ATPase activity have suggested that there is more than one functional type of Na-K ATPase in the central nervous system. Molecular cloning has demonstrated that there are three different genes encoding catalytic (alpha) subunits and at least two genes encoding glycoprotein (beta) subunits; all are expressed in the brain. This brief review summarizes the current understanding of Na-K ATPase isozyme distribution and properties. Both neurons and glia can express different isoforms in a cell-specific manner.