Working memory gates visual input to primate prefrontal neurons.
Working memory gates visual input to primate prefrontal neurons.
复制标题
DOI：
10.7554/elife.64814
复制
发表时间：
2021-06-16
期刊：
影响因子：
7.7
通讯作者：
Moore T
中科院分区：
文献类型：
--
作者：
Noudoost B;Clark KL;Moore T
视觉引导的行为依赖于感觉输入和工作记忆（WM）中保存的信息的整合。然而，目前还不清楚这是如何在神经回路的水平上完成的。我们研究了行为猴前额叶皮层视觉区神经元的直接视觉皮层输入。我们发现，视觉输入到前额叶皮层的功效是由WM中的信息控制的。令人惊讶的是，前额叶神经元的视觉输入被发现针对那些具有视觉和运动特性的神经元，而不是优先针对其他视觉神经元。此外，当猴子记住与视觉输入位置相匹配的位置时，视觉皮层诱发的活动幅度更大，更同步，更迅速。这些结果表明，工作记忆直接影响将视觉输入转化为视觉引导行为的回路。
Visually guided behavior relies on the integration of sensory input and information held in working memory (WM). Yet it remains unclear how this is accomplished at the level of neural circuits. We studied the direct visual cortical inputs to neurons within a visuomotor area of prefrontal cortex in behaving monkeys. We show that the efficacy of visual input to prefrontal cortex is gated by information held in WM. Surprisingly, visual input to prefrontal neurons was found to target those with both visual and motor properties, rather than preferentially targeting other visual neurons. Furthermore, activity evoked from visual cortex was larger in magnitude, more synchronous, and more rapid, when monkeys remembered locations that matched the location of visual input. These results indicate that WM directly influences the circuitry that transforms visual input into visually guided behavior.