A model for coordinating nuclear mechanics and membrane remodeling to support nuclear integrity.
A model for coordinating nuclear mechanics and membrane remodeling to support nuclear integrity.
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DOI：
10.1016/j.ceb.2016.03.009
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发表时间：
2016-08
影响因子：
7.5
通讯作者：
Lusk CP
中科院分区：
文献类型：
--
作者：
King MC;Lusk CP
核内核纤层蛋白丝的聚合物网络位于核被膜之下，并为后生动物的核提供机械稳定性。最近的工作表明，A型核纤层蛋白的表达与细胞环境的硬度成正比，从而耦合核和细胞外力学。使用血影蛋白-肌动蛋白网络在红细胞质膜作为一个模型，我们考虑如何相对刚度的核支架的影响越来越多的间期特异性核膜重塑事件，包括最近发现的，核膜专门的质量控制机制。我们认为，一个更硬的椎板阻碍这些重塑事件，需要局部椎板重塑和/或伴随缩放的膜重塑机制，在核膜的功效。
A polymer network of intranuclear lamin filaments underlies the nuclear envelope and provides mechanical stability to the nucleus in metazoans. Recent work demonstrates that the expression of A-type lamins scales positively with the stiffness of the cellular environment, thereby coupling nuclear and extracellular mechanics. Using the spectrin-actin network at the erythrocyte plasma membrane as a model, we contemplate how the relative stiffness of the nuclear scaffold impinges on the growing number of interphase-specific nuclear envelope remodeling events, including recently discovered, nuclear envelope-specialized quality control mechanisms. We suggest that a stiffer lamina impedes these remodeling events, necessitating local lamina remodeling and/or concomitant scaling of the efficacy of membrane-remodeling machineries that act at the nuclear envelope.
DOI：
10.1083/jcb.82.3.654
发表时间：
1979-09
期刊：
The Journal of cell biology
影响因子：
--
作者：
Hardy B;Bensch KG;Schrier SL
通讯作者：
Schrier SL