Recent cannabis use and myocardial infarction in young adults: a cross-sectional study.
Recent cannabis use and myocardial infarction in young adults: a cross-sectional study.
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DOI：
10.1503/cmaj.202392
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发表时间：
2021-09-07
期刊：
影响因子：
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通讯作者：
Mazer CD
中科院分区：
文献类型：
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作者：
Ladha KS;Mistry N;Wijeysundera DN;Clarke H;Verma S;Hare GMT;Mazer CD
年轻人中大麻的使用正在增加，但其对心血管健康的影响却知之甚少。我们的目的是评估年轻人（18-44 岁）近期使用大麻与心肌梗塞 (MI) 病史之间的关联。我们使用 2017 年和 2018 年美国成年人行为风险因素监测系统调查队列的汇总数据进行了一项横断面研究。我们使用加权逻辑回归模型分析了近期使用大麻与心肌梗死病史之间的关联，该模型根据人口因素、社会经济因素、健康相关行为、伴随物质使用和其他合并症进行了调整。我们还在按使用频率和主要消费方式分层后评估了这种关联。在 33 173 名年轻人（加权 1850 万人）中，4610 名受访者（加权 320 万人）报告了最近使用大麻的情况（17.5%，95% 置信区间 [CI] 16.8%–18.2%）。相对于非吸食者（n = 28 563 人中的 240 人 [0.8%]，调整后优势比 [OR] 2.07，95% CI 1.12–3.82），最近吸食大麻的人（n = 4610 人中的 61 人，1.3%）有 MI 病史的频率更高。心肌梗死病史与每月使用大麻超过 4 次有关（调整后 OR 2.31，95% CI 1.18–4.50），并且与吸烟作为主要消费方式相关（调整后 OR 2.01，95% CI 1.02–3.98）。我们的研究提供了证据支持年轻人最近使用大麻与心肌梗死史之间的关联。高危人群增加大麻使用可能会对心血管健康产生负面影响。
Cannabis use is increasing among young adults, but its effects on cardiovascular health are poorly understood. We aimed to assess the association between recent cannabis use and history of myocardial infarction (MI) in young adults (aged 18–44 yr). We performed a cross-sectional study using pooled data from the 2017 and 2018 cohorts of the American Behavioral Risk Factor Surveillance System survey of US adults. We analyzed the association between any recent cannabis use and history of MI using a weighted logistic regression model that adjusted for demographic factors, socioeconomic factors, health-related behaviours, concomitant substance use and other comorbidities. We also assessed this association after stratifying by frequency of use and by primary method of consumption. Among 33 173 young adults (18.5 million weighted), 4610 respondents (3.2 million weighted) reported recent cannabis use (17.5%, 95% confidence interval [CI] 16.8%–18.2%). A history of MI was more frequent among recent cannabis users (n = 61 of 4610, 1.3%) relative to nonusers (n = 240 of 28 563 [0.8%], adjusted odds ratio [OR] 2.07, 95% CI 1.12–3.82). A history of MI was associated with cannabis use of more than 4 times per month (adjusted OR 2.31, 95% CI 1.18–4.50), and with smoking as a primary method of consumption (adjusted OR 2.01, 95% CI 1.02–3.98). Our study provides evidence supporting an association between recent cannabis use and history of MI in young adults. Increasing cannabis use in an at-risk population could have negative implications for cardiovascular health.