TROPOELASTIN HETEROGENEITY - IMPLICATIONS FOR PROTEIN FUNCTION AND DISEASE
TROPOELASTIN HETEROGENEITY - IMPLICATIONS FOR PROTEIN FUNCTION AND DISEASE
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DOI：
10.1165/ajrcmb/2.5.399
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发表时间：
1990-05-01
影响因子：
6.4
通讯作者：
DEAK, SB
中科院分区：
文献类型：
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作者：
PARKS, WC;DEAK, SB
弹性纤维由形态和化学性质不同的两种成分组成。大多数成熟纤维（> 90%）是无定形弹性蛋白，是交联原弹性蛋白单体的不溶性产物。原弹性蛋白富含非极性氨基酸，例如丙氨酸、缬氨酸和脯氨酸以及不带电荷的氨基酸甘氨酸。这种氨基酸组成导致疏水相互作用，这对于纤维 (3) 的弹性性能是必需的。微原纤维是弹性纤维的另一种成分，是一种糖蛋白复合物，由直径为 10 至 12 纳米的小原纤维组成 (4, 5)。微原纤维含有许多带电和碱性氨基酸残基以及大量半胱氨酸。这种差异在
Elastic fibers are comprised of two components that are morphologically and chemically distinct. Most of the mature fiber (> 90%) is amorphous elastin, theinsoluble product of crosslinked tropoelastin monomers. Tropoelastin is rich in nonpolar amino acids, such as alanine, valine, and proline and the uncharged amino acid glycine. This amino acid composition results in hydrophobic interactions which are necessary for the elastic property of the fiber (3). Microfibrils, the other component of elastic fibers, are a complex of glycoproteins organized as small, 10-to 12-nm-diameter fibrils (4, 5). Microfibrils contain many charged and basic amino acid residues as well as numerous cysteines. This difference in