Development of a bronchospasm device model.
Development of a bronchospasm device model.
复制标题
支气管痉挛装置模型的开发。
DOI：
10.1007/s00540-014-1872-0
复制
发表时间：
2015
期刊：
影响因子：
2.8
通讯作者：
Kawamae K.
中科院分区：
文献类型：
--
作者：
Sugiura A;Kawamae K.
没有强有力的证据支持对呼气流量的严重限制进行通气管理，例如麻醉期间的支气管痉挛或严重哮喘和慢性阻塞性肺疾病（COPD）的急性加重。由于导致呼吸和血流动力学不稳定，动物模型不能用于开发可重复的实验模型，以进行与这些病因相关的机械通气策略研究。因此，我们通过修改呼气末正压（PEEP）阀开发了一种装置模型，该模型可以模拟气道支气管收缩的特征（即呼气峰流量有限和呼气期延长）。这些特征在呼气口变窄后得到改善。我们相信该装置模型将为未来的机械通气实验提供便利。
There is no strong evidence to support ventilatory management for critical limitation of expiratory flow, such as bronchospasm during anesthesia or an acute exacerbation of severe asthma and chronic obstructive pulmonary disease (COPD). Animal models cannot be used to develop reproducible experimental models for conducting mechanical ventilation strategy research relating to these etiologies due to the resulting respiratory and hemodynamic instabilities. Therefore, we developed a device model by modifying a positive end-expiratory pressure (PEEP) valve that can simulate the characteristics of airway bronchoconstriction (i.e., limited peak expiratory flow and a prolonged expiratory phase). These characteristics were found to improve upon narrowing the expiratory port. We believe that this device model will facilitate future mechanical ventilation experiments.