Indole alkaloids from three species of the Ervatamia genus: E. officinalis, E. divaricata, and E. divaricata Gouyahua.
Indole alkaloids from three species of the Ervatamia genus: E. officinalis, E. divaricata, and E. divaricata Gouyahua.
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DOI：
10.1021/np060344o
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发表时间：
2007-01
影响因子：
5.1
通讯作者：
Hua Zhang;Xiao-Ning Wang;Li-ping Lin;Jian Ding;J. Yue
中科院分区：
文献类型：
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作者：
Hua Zhang;Xiao-Ning Wang;Li-ping Lin;Jian Ding;J. Yue
六种新的吲哚生物碱：14，15-二异丙基-10，11-二甲氧基-16-表长春胺（1），14，15-二异丙基-10-羟基-11-甲氧基-16-表长春胺（2），14，15-二异丙基-10，11-二甲氧基长春胺（3），14，15-二异丙基-10-羟基-11-甲氧基长春胺（4），19，20-二异丙基-6 α-羟基ervatamine（5），和脱羟基麦角胺醇（dehydroxyervataminol，6），以及沿着的36种已知吲哚生物碱。officinalis，E. divaricata和E. divaricata Gouyahua，狗牙花属。根据波谱学方法和化学相关性对这些生物碱的结构进行了表征。评价了除7、18、27、38、40和44外的所有生物碱对P-388小鼠白血病细胞和A-549人肺癌细胞的体外细胞毒活性。只有二聚吲哚生物碱表现出细胞毒活性。
Six new indole alkaloids, 14,15-didehydro-10,11-dimethoxy-16-epivincamine (1), 14,15-didehydro-10-hydroxy-11-methoxy-16-epivincamine (2), 14,15-didehydro-10,11-dimethoxyvincamine (3), 14,15-didehydro-10-hydroxy-11-methoxyvincamine (4), 19,20-didehydro-6alpha-hydroxyervatamine (5), and dehydroxyervataminol (6), along with 36 known indole alkaloids, were isolated from three species, E. officinalis, E. divaricata, and E. divaricata Gouyahua, of the Ervatamia genus. The structures of these alkaloids were characterized on the basis of spectroscopic methods and chemical correlation. The in vitro cytotoxic activities of all the alkaloids except 7, 18, 27, 38, 40, and 44 against the tumor cell lines P-388 murine leukemia and A-549 human lung carcinoma were evaluated. Only the dimeric indole alkaloids showed cytotoxic activities.