Talk is cheap-cross-talk in establishment, maintenance, and readout of chromatin modifications
Talk is cheap-cross-talk in establishment, maintenance, and readout of chromatin modifications
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DOI：
10.1101/gad.1759708
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发表时间：
2008-12-15
影响因子：
10.5
通讯作者：
Fischle, Wolfgang
中科院分区：
文献类型：
--
作者：
Fischle, Wolfgang
细胞基因组的功能在染色质水平上受到表观遗传控制。组蛋白的多重翻译后修饰与 DNA 甲基化在指导染色质的不同功能状态中发挥着关键作用。事实证明，染色质平台上的许多表观遗传标记并不是独立发挥作用，而是相互串扰。在本期《基因与发育》中，Adhvaryu 和 Selker（第 3391-3396 页）对涉及组蛋白磷酸化、组蛋白甲基化和 DNA 甲基化的复杂调控网络提供了新颖的见解。
The functionality of a cell's genome is controlled epigenetically on the level of chromatin. Multiple post-translational modifications of histone proteins together with DNA methylation play a key role in directing distinct functional states of chromatin. As it emerges, many epigenetic marks on the chromatin platform do not act independently, but cross-talk with each other. In this issue of Genes & Development, Adhvaryu and Selker (pp. 3391-3396) provide novel insights into an intricate regulatory network involving histone phosphorylation, histone methylation, and DNA methylation.