MANIPULATION OF THE ALDOL ADDUCTS FROM LACTATE-DERIVED KETONES - A VERSATILE CHIRAL AUXILIARY FOR THE ASYMMETRIC-SYNTHESIS OF BETA-HYDROXY CARBONYL-COMPOUNDS
MANIPULATION OF THE ALDOL ADDUCTS FROM LACTATE-DERIVED KETONES - A VERSATILE CHIRAL AUXILIARY FOR THE ASYMMETRIC-SYNTHESIS OF BETA-HYDROXY CARBONYL-COMPOUNDS
复制标题
DOI：
10.1016/0040-4039(94)88435-8
复制
发表时间：
1994-11-28
影响因子：
1.8
通讯作者：
WALLACE, DJ
中科院分区：
文献类型：
--
作者：
PATERSON, I;WALLACE, DJ
酮1和酮2可以转化为多种对映体纯的反式和合成式α-甲基-β-羟基酮和醛。可以保留5和11中的α‘-甲基，表明乳酸衍生基团作为任选的手性助剂的用途。
The ketones 1 and 2 can be transformed into a wide range of enantiomerically-pure anti and syn alpha-methyl-beta-hydroxy ketones and aldehydes. The alpha'-methyl group in 5 and 11 may be retained, demonstrating the use of the lactate-derived group as an optional chiral auxiliary.