Global trends in antimicrobial resistance in animals in low- and middle-income countries
Global trends in antimicrobial resistance in animals in low- and middle-income countries
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DOI：
10.1126/science.aaw1944
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发表时间：
2019-09-20
期刊：
影响因子：
56.9
通讯作者：
Laxminarayan, Ramanan
中科院分区：
文献类型：
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作者：
Van Boeckel, Thomas P.;Pires, Joao;Laxminarayan, Ramanan
全球对动物蛋白需求的扩大是我们这个时代最显著的饮食趋势。动物的抗菌素消费量是人类的三倍，并使大规模动物蛋白生产成为可能。与人类相比，动物中抗菌素耐药性发展的后果受到的关注相对较少。我们分析了发展中国家901点病原体流行调查，以绘制动物耐药性图。中国和印度是最大的耐药热点，巴西和肯尼亚也出现了新的热点。从2000年到2018年，耐药性超过50%的抗菌素比例在鸡中从0.15增加到0.41，在猪中从0.13增加到0.34。预计动物耐药性的不断升级将对动物健康并最终对人类健康产生重要影响。
The global scale-up in demand for animal protein is the most notable dietary trend of our time. Antimicrobial consumption in animals is threefold that of humans and has enabled large-scale animal protein production. The consequences for the development of antimicrobial resistance in animals have received comparatively less attention than in humans. We analyzed 901 point prevalence surveys of pathogens in developing countries to map resistance in animals. China and India represented the largest hotspots of resistance, with new hotspots emerging in Brazil and Kenya. From 2000 to 2018, the proportion of antimicrobials showing resistance above 50% increased from 0.15 to 0.41 in chickens and from 0.13 to 0.34 in pigs. Escalating resistance in animals is anticipated to have important consequences for animal health and, eventually, for human health.