In vitro experiments and numerical simulations of airflow in realistic nasal airway geometry
In vitro experiments and numerical simulations of airflow in realistic nasal airway geometry
复制标题
DOI：
10.1007/s10439-006-9094-8
复制
发表时间：
2006-06-01
影响因子：
3.8
通讯作者：
Louis, Bruno
中科院分区：
文献类型：
--
作者：
Croce, Celine;Fodil, Redouane;Louis, Bruno
将在鼻腔和上颌窦的人体塑化标本中测量的压力-流量关系与通过塑化标本的 CT 扫描发出的数值三维重建中的数值气流模拟获得的压力-流量关系进行比较。在实验中，使用三种不同的气体（HeO2、空气和 SF6）测试了高达 1500 ml/s 的流速。使用层流模型的 CFD 软件在稳态条件下使用基于有限体积的方法对两个鼻孔中高达 353 ml/s 的流速进行数值吸气气流模拟。在流速高达 250 ml/s 时观察到的测量总压降与数值计算总压降之间的良好一致性是验证 CFD 软件描述生理学真实双鼻模型中流量的能力的重要一步。主要的总压降位于鼻瓣区域。发现气流在鼻腔的下正中部分占主导地位。在鼻瓣下游和嗅觉区域观察到两个主要涡流。未来，CFD 软件将成为临床医生的有用工具，让他们更好地了解鼻腔中三维呼吸流的复杂性，从而更适当地管理患者的症状。
Pressure-flow relationships measured in human plastinated specimen of both nasal cavities and maxillary sinuses were compared to those obtained by numerical airflow simulations in a numerical three-dimensional reconstruction issued from CT scans of the plastinated specimen. For experiments, flow rates up to 1500 ml/s were tested using three different gases: HeO2, Air, and SF6. Numerical inspiratory airflow simulations were performed for flow rates up to 353 ml/s in both the nostrils using a finite-volume-based method under steady-state conditions with CFD software using a laminar model. The good agreement between measured and numerically computed total pressure drops observed up to a flow rate of 250 ml/s is an important step to validate the ability of CFD software to describe flow in a physiologically realistic binasal model. The major total pressure drop was localized in the nasal valve region. Airflow was found to be predominant in the inferior median part of nasal cavities. Two main vortices were observed downstream from the nasal valve and toward the olfactory region. In the future, CFD software will be a useful tool for the clinician by providing a better understanding of the complexity of three-dimensional breathing flow in the nasal cavities allowing more appropriate management of the patient's symptoms.