Hematocrit and hemoglobin values are negatively correlated with insulin resistance in spontaneous hypertension.
Hematocrit and hemoglobin values are negatively correlated with insulin resistance in spontaneous hypertension.
复制标题
自发性高血压的血细胞比容和血红蛋白值与胰岛素抵抗呈负相关。
作者：
V. Zídek;A. Fučíková;A. Musilová;V. Bílá;V. Křen;M. Pravenec
最近有报道称，人类红细胞压积和血红蛋白值升高通常伴随着胰岛素抵抗和代偿性高胰岛素血症。在目前的研究中，我们分析了红细胞压积/血红蛋白之间的关系，一方面和胰岛素抵抗，血脂异常，另一方面在HXB/BXH重组近交系（RI）来自自发性高血压大鼠（SHR）和布朗挪威（BN）大鼠。与BN祖细胞相比，SHR祖细胞株具有显著增加的红细胞压积值，并且还具有高血压和胰岛素抵抗。RI株之间的红细胞压积和血红蛋白值的分布是连续的，这表明一个多基因遗传模式。RI菌株的分析表明，血红蛋白与胰岛素和胰岛素/葡萄糖比值呈负相关，红细胞压积与胰岛素刺激的葡萄糖摄取在分离的脂肪细胞呈负相关。RI株的血液学参数与血压或血脂表型之间无相关性。目前的研究结果表明，红细胞压积和血红蛋白值可能被添加到与SHR品系胰岛素抵抗综合征相关的聚类变量中。
It has been recently reported that increased hematocrit and hemoglobin values often accompany insulin resistance and compensatory hyperinsulinemia in humans. In the current study, we analyzed the relationship between hematocrit/hemoglobin on the one hand and insulin resistance, dyslipidemia, and hypertension on the other hand in HXB/BXH recombinant inbred (RI) strains derived from the spontaneously hypertensive rat (SHR) and the Brown Norway (BN) rat. The SHR progenitor strain had a significantly increased hematocrit values and it was also hypertensive and insulin-resistant when compared with the BN progenitor. The distribution of hematocrit and hemoglobin values among RI strains was continuous, suggesting a polygenic mode of inheritance. Analysis of RI strains revealed that hemoglobin was negatively correlated with insulin and insulin/glucose ratio, and that hematocrit was negatively correlated with insulin-stimulated glucose uptake in isolated adipocytes. There was no relationship between hematological parameters and blood pressure or lipid phenotypes in RI strains. The findings of the current study suggest that hematocrit and hemoglobin values might be added to the clustering variables related to the insulin resistance syndrome in the SHR strain.