Thyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations: A repeated measures study.
Thyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations: A repeated measures study.
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DOI：
10.1016/j.envint.2017.04.001
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发表时间：
2017-07
影响因子：
11.8
通讯作者：
Meeker JD
中科院分区：
文献类型：
--
作者：
Aung MT;Johns LE;Ferguson KK;Mukherjee B;McElrath TF;Meeker JD
孕妇孕期甲状腺激素的供应在胎儿发育中起着至关重要的作用。虽然动物和体外研究提供了双酚A(BPA)暴露导致甲状腺激素紊乱的证据，但在人类研究中仍然缺乏证据，特别是在怀孕的情况下。我们的目的是探索妊娠期间尿BPA浓度与血浆甲状腺激素参数之间的关系，并调查妊娠期间潜在的易感窗口。我们的研究人群包括116例早产病例和323例对照，来自嵌套病例对照研究。我们测量了怀孕期间最多四次研究访问(每次访问的中位数分别为9.64周、17.9周、26.0周和35.1周)收集的尿中BPA和血浆中的甲状腺激素参数。我们使用线性混合模型进行重复测量分析，并通过研究访问分层的多变量线性回归模型来探索潜在的易感窗口。在我们的重复测量分析中，双酚A和促甲状腺激素(TSH)呈负相关。BPA的四分位数范围增加与促甲状腺激素降低8.21%(95%可信区间：−14.2，−1.83)和游离T4增加4.79%(95%可信区间：0.82，8.92)相关。在我们第3次和第4次的横断面分析中，双酚A和促甲状腺激素也呈负相关。我们的结果表明，在整个妊娠期间，促甲状腺激素与尿双酚A以一致的方式呈负相关。妊娠期间TSH水平的紊乱可能会影响孩子的发育，并干扰正常的分娩结果。
Maternal supply of thyroid hormones during pregnancy serves a critical role in fetal development. Although animal and in vitro studies provide evidence for thyroid hormone disruption as a result of bisphenol A (BPA) exposure, there is still a lack of evidence in human studies, particularly in the context of pregnancy. We aimed to explore the associations between urinary BPA concentrations and plasma thyroid hormone parameters during gestation in pregnant women, and also investigated potential windows of vulnerability during gestation. Our study population included 116 cases of preterm birth and 323 controls from a nested case-control study. We measured BPA in urine and thyroid hormone parameters in plasma samples collected at up to four study visits during pregnancy (median for each visit: 9.64, 17.9, 26.0, and 35.1 weeks gestation). We used linear mixed models for repeated measures analyses, and multivariate linear regression models stratified by study visit to explore potential windows of susceptibility. In our repeated measures analysis, BPA and thyroid stimulating hormone (TSH) were inversely associated. An interquartile range (IQR) increase in BPA was associated with an 8.21 % decrease in TSH (95% confidence interval [CI]: −14.2, −1.83), and a 4.79% increase in free T4 (95% CI: 0.82, 8.92). BPA and TSH were also inversely associated in our cross-sectional analyses at visits 3 and 4. Our results suggest that TSH is inversely associated with urinary BPA in a consistent manner across pregnancy. Disruption of TSH levels during pregnancy can potentially impact child development and interfere with normal birth outcomes.