Zero-field remote detection of NMR with a microfabricated atomic magnetometer
Zero-field remote detection of NMR with a microfabricated atomic magnetometer
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DOI：
10.1073/pnas.0711505105
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发表时间：
2008-02-19
影响因子：
11.1
通讯作者：
Pines, A.
中科院分区：
文献类型：
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作者：
Ledbetter, M. P.;Savukov, I. M.;Pines, A.
我们演示了远程检测核磁共振（NMR）与微芯片传感器组成的微流体通道和微制造的蒸汽细胞（原子磁力计的心脏）。检测发生在零磁场下，这允许磁力计在无自旋交换弛豫（SERF）状态下操作，并通过消除对螺线管的需要来增加传感器和样品的接近度以产生前导场。我们实现了脉冲NMR线宽为26 Hz，有限的，我们相信，在编码区域的停留时间和流动分散。在一个完全优化的系统中，我们估计，对于1秒的积分，在10-kG场中预极化的1 mm（3）体积中的7 x 10（13）个质子，可以检测到信噪比约为3。这种灵敏度水平与100 kG磁场中的微线圈具有竞争力，而不需要超导磁体。
We demonstrate remote detection of nuclear magnetic resonance (NMR) with a microchip sensor consisting of a microfluidic channel and a microfabricated vapor cell (the heart of an atomic magnetometer). Detection occurs at zero magnetic field, which allows operation of the magnetometer in the spin-exchange relaxation-free (SERF) regime and increases the proximity of sensor and sample by eliminating the need for a solenoid to create a leading field. We achieve pulsed NMR linewidths of 26 Hz, limited, we believe, by the residence time and flow dispersion in the encoding region. In a fully optimized system, we estimate that for 1 s of integration, 7 x 10(13) protons in a volume of 1 mm(3), prepolarized in a 10-kG field, can be detected with a signal-to-noise ratio of approximate to 3. This level of sensitivity is competitive with that demonstrated by microcoils in 100-kG magnetic fields, without requiring superconducting magnets.