A reassessment of the in-vitro activity of colistin sulphomethate sodium
A reassessment of the in-vitro activity of colistin sulphomethate sodium
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DOI：
10.1093/jac/39.2.255
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发表时间：
1997-02-01
影响因子：
5.2
通讯作者：
Wise, R
中科院分区：
文献类型：
--
作者：
Catchpole, CR;Andrews, JM;Wise, R
比较了粘菌素甲磺酸钠与其他常用抗菌药物对近期临床分离的377株革兰阴性杆菌(包括94株囊性纤维化患者分离的铜绿假单胞菌)和16株明确耐药模式的细菌的体外抗菌活性。粘菌素对大多数铜绿假单胞菌(MIC90 4 mg/L)、志贺氏菌属(Shigella spp.)(MIC900.5 mg/L)，沙门氏菌属。(MIC90 1 mg/L)，不动杆菌属。(MIC90 2 mg/L)，柠檬酸杆菌属。大肠埃希菌(MIC90 1 mg/L)、克雷伯氏菌(Klebsiella spp.)(MIC90 8 mg/L)和肠杆菌属。(MIC90 1 mg/L)，对普罗迪亚丝虫无有效活性。或沙雷氏菌属。结果表明，粘菌素仍然是一种有用的抗菌剂，对革兰氏阴性菌，特别是那些对更常用的抗生素具有耐药性的菌株。
The in-vitro activity of colistin sulphomethate sodium was compared with that of other commonly used antimicrobial agents against 377 recent clinical isolates of Gram-negative bacteria (including 94 strains of Pseudomonas aeruginosa from patients with cystic fibrosis) and 16 organisms with defined resistance patterns. Colistin was active against most strains of P. aeruginosa (MIC90 4 mg/L), Shigella spp. (MIC90 0.5 mg/L), Salmonella spp. (MIC90 1 mg/L), Acinetobacter spp. (MIC90 2 mg/L), Citrobacter spp. (MIC90 1 mg/L), Escherichia coli (MIC90 1 mg/L), Klebsiella spp. (MIC90 8 mg/L) and Enterobacter spp. (MIC90 1 mg/L), No useful activity was demonstrated against Providentia spp. or Serratia spp. The results show that colistin remains a useful antimicrobial agent against Gram-negative bacteria, particularly those strains which are resistant to more commonly used antibiotics.