Methods for etiologic and early marker investigations in the PLCO trial
Methods for etiologic and early marker investigations in the PLCO trial
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DOI：
10.1016/j.mrfmmm.2005.06.013
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发表时间：
2005-12-30
影响因子：
2.3
通讯作者：
Berg, CD
中科院分区：
文献类型：
--
作者：
Hayes, RB;Sigurdson, A;Berg, CD
随着生物标志物和新技术的快速发展，大规模的基于生物学的队列研究为基于人群的疾病病因学和早期检测标志物研究提供了越来越多的机会。前列腺癌、肺癌、结直肠癌和卵巢癌 (PLCO) 筛查试验是一项大型随机试验，旨在确定筛查这些癌症是否会降低这些疾病的死亡率。在该试验中，PLCO 病因学和早期标志物研究 (EEMS) 确定了癌症和其他疾病的危险因素，并评估了早期检测疾病的生物标志物。 EEMS 包括 155,000 名志愿者，他们提供基本的风险因素信息。在六轮筛查的每一轮中，从筛查组参与者（77,000 名受试者）收集系列血液样本（包括一次冷冻保存全血的收集），并从试验的对照组参与者收集口腔细胞。病因学研究考虑环境（例如饮食）、生化和遗传因素。早期检测研究侧重于早期疾病的血液生物标志物。临床流行病学也是 PLCO 试验的重要组成部分。由 Elsevier B.V. 出版
With the rapid development of biomarkers and new technologies, large-scale biologically-based cohort studies present expanding opportunities for population-based research on disease etiology and early detection markers. The prostate, lung, colorectal and ovarian cancer (PLCO) screening trial is a large randomized trial designed to determine if screening for these cancers leads to mortality reduction for these diseases.Within the Trial, the PLCO etiology and early marker study (EEMS) identifies risk factors for cancer and other diseases and evaluates biologic markers for the early detection of disease. EEMS includes 155,000 volunteers who provide basic risk factor information. Serial blood samples are collected at each of six screening rounds (including one collection for cryopreserved whole blood) from screening arm participants (77,000 subjects) and buccal cells are collected from those in the control arm of the trial.Etiologic studies consider environmental (e.g., diet), biochemical, and genetic factors. Early detection studies focus on blood-based biologic markers of early disease. Clinical epidemiology is also an important component of the PLCO trial. Published by Elsevier B.V.