Morphology of bronchial epithelium adjacent to adenocarcinoma of the lung.
Morphology of bronchial epithelium adjacent to adenocarcinoma of the lung.
复制标题
邻近肺腺癌的支气管上皮的形态。
DOI：
--
复制
发表时间：
1990
期刊：
影响因子：
--
通讯作者：
H. Spjut
中科院分区：
文献类型：
--
作者：
M. D. Solomon;S. Greenberg;H. Spjut
对22例原发性腺癌肺叶切除标本的大体无异常支气管和细支气管进行了显微镜检查。切片取自包含癌的节段，并与同一标本中未受累节段的切片进行比较，以检查癌前病变。平均肿瘤大小为3.75 cm（1.5 - 11 cm）。患者的平均年龄为60.4岁（29至79岁）; 13名男性和9名女性;均为吸烟者，平均年龄为44.1包-年（20至100包-年）。6例标本（27%）显示无组织学变化。在9个样本（41%）中发现局灶性鳞状上皮化生，但在9个样本中的4个（44%）中，在致癌段中未观察到。在6个标本（27%）中观察到局灶性杯状细胞化生，但在6个标本中的2个（33%）中，它不在致癌段中。在两个标本（9%）的致癌段和其他地方的局灶性基底细胞增生。在两个标本（9%）中发现了一个轻度上皮异型增生的单一病灶，但这些病灶不在致癌段。在三个样本（14%）中观察到局灶性上皮再生，但其中两个（66）不在致癌段。这种呼吸道上皮的显微镜下异常与吸烟有关，每一种都是潜在的癌前病变;然而，我们的研究表明，在肺腺癌中，呼吸道上皮没有组织学上可识别的变化，这些变化始终标志着癌前病变。
Gross unremarkable bronchi and bronchioles from 22 lobectomy specimens containing primary adenocarcinoma were examined microscopically. Sections were taken from the segment containing the carcinoma and compared with sections taken from uninvolved segments in the same specimen to examine for premalignant lesions. The average tumor size was 3.75 cm (1.5 to 11 cm). The average age of patients was 60.4 yr (29 to 79 yr); 13 were men and nine were women; all were smokers, and the average was 44.1 pack-years (20 to 100 pack-years). Six of the specimens (27%) showed no histologic changes. Focal squamous metaplasia was identified in nine specimens (41%), but in four of the nine (44%), it was not seen in the carcinogenic segment. Focal goblet cell metaplasia was seen in six specimens (27%), but in two of the six (33%), it was not in the carcinogenic segment. Focal basal cell hyperplasia was seen in two specimens (9%) within both the carcinogenic segment and elsewhere. A single focus of mild epithelial dysplasia was found in each of two specimens (9%), but these foci were not in the carcinogenic segment. Focal epithelial regeneration was noted in three specimens (14%), but two of these (66) were not in the carcinogenic segment. Such microscopic abnormalities of respiratory epithelium are associated with cigarette smoking, and each is a potentially premalignant change; however, our study demonstrated no histologically identifiable changes in the respiratory epithelium that consistently mark for premalignant atypia in the lung adenocarcinoma.