A hypothesis for dietary components as blocking agents of chemical carcinogenesis: plant phenolics and pyrrole pigments.
A hypothesis for dietary components as blocking agents of chemical carcinogenesis: plant phenolics and pyrrole pigments.
复制标题
DOI：
10.1080/01635588509513807
复制
发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
Newmark, H L
中科院分区：
文献类型：
--
作者：
Newmark, H L
化学致癌作用的启动涉及细胞内形成高反应性亲电体，该亲电体可以攻击细胞中的许多化学亲核体，包括DNA，这一过程似乎是启动的中心机制。细胞中的竞争性化学亲核试剂，如内源性谷胱甘肽，可以作为保护或阻断剂，防止DNA受到攻击。在我们的食品供应中，有一些化学物质可以作为抗癌剂或抗突变剂，通过在亲核化学反应中阻断或捕获终极致癌物亲电体，形成无害的产品。这些物质的持续输入可以作为防止DNA损伤的额外缓冲剂，从质和量上补充自然系统。某些植物酚类物质可以是化学诱变剂和/或致癌物的有效抑制剂。某些植物和动物的四吡咯和卟啉也可以作为封闭剂。植物酚类和卟啉都主要对芳香族致癌物有活性。它们不太可能有效作为阻断剂对非芳香族致癌物，或那些没有芳香族基团在接近的最终致癌物亲电基团。
Initiation of chemical carcinogenesis involves the intracellular formation of a highly reactive electrophile that can attack many chemical nucleophiles in the cell, including DNA, a process that seems to be the central mechanism of initiation. Competing chemical nucleophiles in the cell, such as endogenous glutathione, can act as protecting or blocking agents against the attack on DNA. There are chemical substances in our food supply that may act as anticarcinogens or antimutagens by blocking or trapping ultimate-carcinogen electrophiles in a nucleophilic chemical reaction, to form innocuous products. A continuous input of these substances could serve as an additional buffer against DNA damage, supplementing the natural systems qualitatively and quantitatively. Certain plant phenolics can be effective inhibitors of chemical mutagens and/or carcinogens. Certain tetrapyrroles and porphyrins, both plant and animal, can also act as blocking agents. Both plant phenolics and porphyrins are primarily active against aromatic carcinogens. They are unlikely to be effective as blocking agents against nonaromatic carcinogens, or those with no aromatic groups in close proximity to the ultimate-carcinogen electrophilic group.