Local infusion of prostaglandin E1 stimulates mandibular bone formation in vivo.
Local infusion of prostaglandin E1 stimulates mandibular bone formation in vivo.
复制标题
局部输注前列腺素 E1 可刺激体内下颌骨形成。
DOI：
10.1111/j.1600-0714.1988.tb01324.x
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Miller,S
中科院分区：
文献类型：
--
作者：
MarksJr,SC;Miller,S
牙槽骨的维持是牙科临床的一个主要目标。这在牙周炎或牙列缺失（残余牙脊吸收）等局部炎症发作后尤其困难。我们从比格犬身上得到证据，局部注射前列腺素E1(PGE) 3周，剂量为每周500至2000μg，在下颌骨产生显著的、局部的牙槽骨形成，通过荧光显微镜和显微放射学评估，显示出正常的板层结构和矿化模式。这种新形成的骨是否能在功能上与骨骼结合，并能取代因手术切除或创伤而丢失的骨，仍有待确定。然而，这些数据表明PGE输注可能最终产生可预测的局部成骨。
The maintenance of alveolar bone is a major clinical objective in dentistry. This is particularly difficult following such local inflammatory episodes as those of periodontitis or the loss of dentition (residual ridge resorption). We present evidence from beagle dogs that local infusion of prostaglandin E1(PGE) for 3 weeks at doses of 500 to 2000μg per week produces a dramatic, localized formation of alveolar bone in the mandible which exhibits a normal lamellar architecture and mineralization pattern when evaluated by fluorescence microscopy and microradiography. Whether this newly formed bone becomes functionally integrated into the skeleton and can replace bone lost from surgical resections or trauma remains to be established. Nevertheless, these data indicate that predictable local osteogenesis may eventually be produced by infusions of PGE.