Diabetes Mellitus Induces Alzheimer's Disease Pathology: Histopathological Evidence from Animal Models.
Diabetes Mellitus Induces Alzheimer's Disease Pathology: Histopathological Evidence from Animal Models.
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DOI：
10.3390/ijms17040503
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发表时间：
2016-04-05
影响因子：
5.6
通讯作者：
Kimura N
中科院分区：
文献类型：
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作者：
Kimura N
阿尔茨海默病(AD)是导致痴呆的主要疾病，其病理特征是脑内老年斑(SP)和神经原纤维缠结(NFT)的积聚。虽然遗传学研究表明β-淀粉样蛋白(A-β)是阿尔茨海默病发病的关键因素，但高龄导致AD的原因尚不清楚。有趣的是，一些流行病学和临床研究表明，II型糖尿病(DM)患者更有可能表现出对AD的易感性。此外，越来越多的证据表明，AD和DM背后的神经病理之间有几个联系，而且有证据表明，实验性的DM诱导会导致认知功能障碍，即使在啮齿动物模型中也是如此。本文综述了糖尿病在动物模型中诱导AD病理的组织病理学证据，并讨论了胰岛素信号异常是诱导AD病理的关键因素的可能性。
Alzheimer’s disease (AD) is the major causative disease of dementia and is characterized pathologically by the accumulation of senile plaques (SPs) and neurofibrillary tangles (NFTs) in the brain. Although genetic studies show that β-amyloid protein (Aβ), the major component of SPs, is the key factor underlying AD pathogenesis, it remains unclear why advanced age often leads to AD. Interestingly, several epidemiological and clinical studies show that type II diabetes mellitus (DM) patients are more likely to exhibit increased susceptibility to AD. Moreover, growing evidence suggests that there are several connections between the neuropathology that underlies AD and DM, and there is evidence that the experimental induction of DM can cause cognitive dysfunction, even in rodent animal models. This mini-review summarizes histopathological evidence that DM induces AD pathology in animal models and discusses the possibility that aberrant insulin signaling is a key factor in the induction of AD pathology.