Physiologic and pharmacologic influences on adrenergic regulation of renin release
Physiologic and pharmacologic influences on adrenergic regulation of renin release
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肾上腺素能调节肾素释放的生理和药理影响
DOI：
10.1002/cpt1977225part1511
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
R. Stone
中科院分区：
文献类型：
--
作者：
S. B. Levy;R. Holle;Larry Hsu;J. Lilley;R. Stone
在高钠和低钠摄入的正常血压和高血压男性中，研究了血压和交感神经系统活动短期变化引起的血流动力学变量和血浆肾素活性（PRA）的变化。记录由标准冷加压试验、亚硝酸戊酯吸入、酚妥拉明输注和苯肾上腺素输注引起的血压和心率变化。在0、5、15和30 min时测定PRA。冷加压试验和吸入亚硝酸戊酯后，两组PRA均无变化。在正常而非高血压受试者中，苯丙氨酸抑制PRA，而在正常血压和高血压受试者中，无论饮食如何，酚妥拉明均升高PRA。短期刺激交感神经系统似乎不会升高人体的PRA。在高血压患者中未观察到α激动剂对PRA的抑制，这可能反映了该组受试者的压力感受器不敏感性。
Changes in hemodynamic variables and plasma renin activity (PRA) induced by short‐term alteration of blood pressure and sympathetic nervous system activity were studied in normotensive and hypertensive men on high‐sodium and low‐sodium intake. Blood pressure and heart rate alterations caused by standard cold pressor tests, amyl nitrite inhalation, phentolamine infusion, and phenylephrine infusion were recorded. PRA was measured at time 0,5, 15, and 30 min. No change in PRA occurred in either group following cold pressor test and amyl nitrite inhalation. Phenylephrine suppressed PRA in normal but not hypertensive subjects, and phentolamine elevated PRA in normotensive and hypertensive subjects regardless of diet. Short‐term stimulation of the sympathetic nervous system does not appear to elevate PRA in man. Suppression of PRA by an alpha agonist was not observed in hypertensives and may reflect barorecptor insensitivity in this group of subjects.