Tissue engineering and the development of Apligraf(R), a human skin equivalent
Tissue engineering and the development of Apligraf(R), a human skin equivalent
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DOI：
10.1016/s0149-2918(97)80043-4
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发表时间：
1997-09-01
影响因子：
3.2
通讯作者：
Falanga, V
中科院分区：
文献类型：
--
作者：
Eaglstein, WH;Falanga, V
近年来，皮肤移植已经从最初的自体移植和同种异体移植的制备发展到生物合成和组织工程化的活体皮肤替代物。这篇综述详细介绍了许多研究者的开创性工作，这些工作导致了组织工程皮肤替代的以下前体：培养的自体角质形成细胞移植物、培养的同种异体角质形成细胞移植物、自体/同种异体复合物、脱细胞胶原基质和细胞基质。它还讨论了开发新产品的基本原理，并描述了导致Aplialum（R）（一种组织工程人类皮肤产品）开发的技术进步。
In recent years, skin grafting has evolved from the initial autograft and allograft preparations to biosynthetic and tissue-engineered living skin replacements. This review details the pioneering work of numerous investigators that led to the following precursors of tissue-engineered skin replacement: cultured autologous keratinocyte grafts, cultured allogeneic keratinocyte grafts, autologous/allogeneic composites, acellular collagen matrices, and cellular matrices. It also discusses the rationale for the development of the newer products and describes the technical advances leading to the development of Apligraf(R), a tissue-engineered human skin product.