A TWIN STUDY OF NONALCOHOL SUBSTANCE-ABUSE
A TWIN STUDY OF NONALCOHOL SUBSTANCE-ABUSE
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DOI：
10.1016/0165-1781(94)02609-m
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发表时间：
1995-04-28
影响因子：
11.3
通讯作者：
VOGLER, GP
中科院分区：
文献类型：
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作者：
GYNTHER, LM;CAREY, G;VOGLER, GP
除了酒精滥用，人们对药物滥用的家庭聚集性知之甚少。在这里，我们报告了华盛顿大学双胞胎系列中使用非酒精物质的双胞胎相似性，其中先证者是通过连续入住圣路易斯地区的精神病院确定的。构建了一个5分的药物滥用量表，其值由从未使用过的药物（1）至药物依赖（5）锚定。出生年份是最有力的药物使用预测因素-年轻的双胞胎得分远高于年长的双胞胎。回归模型中必须考虑遗传力或共同环境，以避免解释方差的显著下降，但无法解决哪个更重要。同卵双胞胎的相关性超过了异卵双胞胎，这表明可能存在遗传因素。
Except for alcohol abuse, little is known about the familial aggregation for substance abuse. Here we report twin resemblance for non-alcohol substance use in the Washington University Twin Series, wherein probands were identified by consecutive admission to psychiatric facilities in the St. Louis area. A 5-point substance abuse scale was constructed with values anchored by never used drugs (1) to drug dependence (5). Year of birth was the most powerful predictor of drug use - younger twins scored far higher than older twins. Either heritability or common environment had to be included in the regression model to avoid a significant drop in explained variance, but which was more important could not be resolved. The correlation for identical twins exceeded that for fraternal twins, suggesting the possibility of a heritable factor.